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Telithromycin

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191114-48-4 Basic informationMore
USE
Telithromycin (Ketek) is an orally bioavailable macrolide.The antibiotic is semisynthetic. Telithromycin is classifiedas a ketolide, and it differs chemically from the macrolidegroup of antibacterials by the lack of α-L-cladinose at 3-position of the erythronolide A ring, resulting in a 3-ketofunction. It is further characterized by imidazolyl andpyridyl rings inked to the macrolide nucleus through a butylchain. The mechanism of action of telithromycin is the sameas that of the macrolide class.<br/>Telithromycin causes a blockade of protein synthesis bybinding to domains II and V of 23S rRNA of the 50S ribosomalsubunit. Because telithromycin binds at domain II,activity against Gram-positive cocci is retained in the presenceof resistance mediated by methylases that alter thedomain V binding site. The antibiotic is also believed to inhibitthe assembly of ribosomes. Resistance to telithromycinoccurs because of riboprotein mutations.
Lastest Price from Telithromycin manufacturers
  • Telithromycin
  • US $0.00 /G
  • CAS:191114-48-4
  • Min. Order: 1G
  • Purity: 98%min
  • Supply Ability: 30kg/month
  • 2024-11-22
  • Telithromycin
  • US $10.50 /KG
  • CAS:191114-48-4
  • Min. Order: 1KG
  • Purity: 99
  • Supply Ability: 1 ton
  • 2024-10-11

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