Leflunomide

• Product Name:Leflunomide
• Synonyms: LEFLUNOMIDE HWA 486 ALPHA,ALPHA,ALPHA-TRIFLUORO-5-METHYL-4-ISOXAZOLECARBOXY-P-TOLUIDIDE 5-METHYLISOXAZOLE-4-(4-TRIFLUOROMETHYLCARBOXANILIDE) 5-METHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]-4-ISOXAZOLECARBOXAMIDE N-(4-TRIFLUOROMETHYLPHENYL)-5-METHYLISOXAZOL-4-CARBOXAMIDE 5-methylisoxazole-4-carboxylicacid(4-trifluoromethyl)anilide 5-methyl-n-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamid
• CAS:75706-12-6
• MF:C12H9F3N2O2
• MW:270.21
• EINECS:616-254-6
• Mol File:75706-12-6.mol
• 

Leflunomide (Arava), an isoxazole prodrug, is an orally activeDMARD marketed in 1998 for the treatment of RA. Itis well absorbed and extensively metabolized in vivo to itsactive metabolite, 2-cyano-3-hydroxy-2-buteneamide (teriflunomide),resulting from a reductive ring opening of theisoxazole ring. Unlike MTX, teriflunomideblocks T-cell proliferation by inhibiting dihydroorotate dehydrogenase,the rate-limiting enzyme in the de novobiosynthesis of pyrimidine that is believed to be responsiblefor the immunosuppressive properties of leflunomide.For this reason, it is not surprising that leflunomide has avery comparable therapeutic efficacy to the first-lineDMARD, MTX as shown in several extended open clinicaltrials. However, even though leflunomide is well toleratedlike MTX, several cases of toxic neuropathy have beenobserved during its use, thus careful monitoring of the patient’sneurological status during treatment is mandatory.Like MTX, leflunomide is contraindicated in pregnancy orin women considering pregnancy.

• Leflunomide
• 
• US $0.00-0.00/Kg/Drum
• CAS:75706-12-6
• Min. Order: 1KG
• Purity: 98%min
• Supply Ability: 1000KGS
• 2024-11-29

• Leflunomide
• 
• US $10.00 /KG
• CAS:75706-12-6
• Min. Order: 1KG
• Purity: 99%
• Supply Ability: 10 mt
• 2024-11-25

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Leflunomide, 98%
  CAS:75706-12-6
  Purity:98% Package:100mg;1g More...
• CB Index:76
• Related Information:Catalog(94657)

• Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
• Tel:821-50328103-801 18930552037
• Products Intro:Product Name:LeflunoMide;5-Methyl-N-[4-(trifluoroMethyl)phenyl]-4-isoxazolecarboxaMide
  CAS:75706-12-6
  Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
• CB Index:69
• Related Information:Catalog(15839)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:LeflunoMide
  CAS:75706-12-6
  Remarks:C14876 More...
• CB Index:61
• Related Information:Catalog(6005)

• Company Name:TCI (Shanghai) Development Co., Ltd.
• Tel:021-67121386
• Products Intro:Product Name:Leflunomide
  CAS:75706-12-6
  Purity:98.0% LC&N Package:1G,200MG More...
• CB Index:81
• Related Information:Catalog(24529)

• Company Name:Beijing HwrkChemical Technology Co., Ltd
• Tel:010-89508211 18501085097
• Products Intro:Product Name:Leflunomide
  CAS:75706-12-6
  Purity:98.50% Package:1g Remarks:HWG25245
• CB Index:55
• Related Information:Catalog(8418)

• Company Name:Beijing Ouhe Technology Co., Ltd
• Tel:010-82967028 13552068683
• Products Intro:Product Name:Leflunomide
  CAS:75706-12-6
  Purity:98% Package:10g;50g;100g;250g;500g More...
• CB Index:60
• Related Information:Catalog(12390)

• Company Name:Nanjing Chemlin Chemical Co., Ltd
• Tel:025-83697070
• Products Intro:Product Name:5-methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide
  CAS:75706-12-6
  Purity:98% Package:10g; 100g; 1kg; 10kg; 100kg; 1000kg; 10g; 100g; 500g More...
• CB Index:64
• Related Information:Catalog(19173)

• Company Name:Shanghai Hanhong Scientific Co.,Ltd.
• Tel:021-54306202 13764082696
• Products Intro:Product Name:Leflunomide
  CAS:75706-12-6
  Purity:98% Remarks:AB07634 More...
• CB Index:64
• Related Information:Catalog(42958)