Leflunomide

• Product Name:Leflunomide
• Synonyms: LEFLUNOMIDE HWA 486 ALPHA,ALPHA,ALPHA-TRIFLUORO-5-METHYL-4-ISOXAZOLECARBOXY-P-TOLUIDIDE 5-METHYLISOXAZOLE-4-(4-TRIFLUOROMETHYLCARBOXANILIDE) 5-METHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]-4-ISOXAZOLECARBOXAMIDE N-(4-TRIFLUOROMETHYLPHENYL)-5-METHYLISOXAZOL-4-CARBOXAMIDE 5-methylisoxazole-4-carboxylicacid(4-trifluoromethyl)anilide 5-methyl-n-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamid
• CAS:75706-12-6
• MF:C12H9F3N2O2
• MW:270.21
• EINECS:616-254-6
• Mol File:75706-12-6.mol
• 

Leflunomide (Arava), an isoxazole prodrug, is an orally activeDMARD marketed in 1998 for the treatment of RA. Itis well absorbed and extensively metabolized in vivo to itsactive metabolite, 2-cyano-3-hydroxy-2-buteneamide (teriflunomide),resulting from a reductive ring opening of theisoxazole ring. Unlike MTX, teriflunomideblocks T-cell proliferation by inhibiting dihydroorotate dehydrogenase,the rate-limiting enzyme in the de novobiosynthesis of pyrimidine that is believed to be responsiblefor the immunosuppressive properties of leflunomide.For this reason, it is not surprising that leflunomide has avery comparable therapeutic efficacy to the first-lineDMARD, MTX as shown in several extended open clinicaltrials. However, even though leflunomide is well toleratedlike MTX, several cases of toxic neuropathy have beenobserved during its use, thus careful monitoring of the patient’sneurological status during treatment is mandatory.Like MTX, leflunomide is contraindicated in pregnancy orin women considering pregnancy.

• Leflunomide
• 
• CAS:75706-12-6
• Min. Order: 1KG
• Purity: 98%min
• Supply Ability: 1000KGS
• 2025-04-21

• Leflunomide
• 
• CAS:75706-12-6
• Min. Order: 1g
• Purity: More Than 99%
• Supply Ability: 100kg/Month
• 2025-01-13

• Company Name:Henan Fengda Chemical Co., Ltd
• Tel:+86-371-86557731
• Products Intro:Product Name:Leflunomide
  CAS:75706-12-6
  Purity:99% Package:1kg;35USD|1000kg;1.2USD
• CB Index:58
• Related Information:Catalog(20111)

• Company Name:BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
• Tel:+86-18600796368
• Products Intro:Product Name:Leflunomide
  CAS:75706-12-6
  Purity:More Than 99% Package:1g
• CB Index:58
• Related Information:Catalog(557)

• Company Name:Capot Chemical Co.,Ltd.
• Tel:+86-（0）57185586718
• Products Intro:Product Name:Leflunomide
  CAS:75706-12-6
  Purity:NLT 98% Package:1G;1KG;100KG
• CB Index:60
• Related Information:Catalog(29625)

• Company Name:ANHUI WITOP BIOTECH CO., LTD
• Tel:
• Products Intro:Product Name:Leflunomide
  CAS:75706-12-6
  
• CB Index:58
• Related Information:Catalog(23504)

• Company Name:Zhejiang J&C Biological Technology Co.,Limited
• Tel:+1-2135480471
• Products Intro:Product Name:Leflunomide
  CAS:75706-12-6
  Purity:99% Package:5KG;1KG Remarks:Leflunomide
• CB Index:58
• Related Information:Catalog(10378)

• Company Name:Hangzhou Proserre Chemical Co.,Ltd.
• Tel:+86-571-86088112
• Products Intro:Product Name:Leflunomide
  CAS:75706-12-6
  Purity:0.99
• CB Index:58
• Related Information:Catalog(1075)

• Company Name:Hefei TNJ Chemical Industry Co.,Ltd.
• Tel:+86-0551-65418684
• Products Intro:Product Name:leflunomide
  CAS:75706-12-6
  
• CB Index:58
• Related Information:Catalog(25333)

• Company Name:Amadis Chemical Company Limited
• Tel:571-89925085
• Products Intro:Product Name:5-methyl-n-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamid
  CAS:75706-12-6
  Purity:0.97 Package:mgs,gs,kgs Remarks:A9622 More...
• CB Index:58
• Related Information:Catalog(131885)