Topotecan
123948-87-8 Basic informationMore
- Product Name:Topotecan
- Synonyms: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)- Hycamptin NSC 609699 SKF 104864 SKF-S 104864 Topotecan lactone Hydrochloric Acid Solution, 0.02N (N/50) Hydrogen chloride, 2N solution in diethyl ether
- CAS:123948-87-8
- MF:C23H23N3O5
- MW:421.45
- EINECS:687-471-1
- Mol File:123948-87-8.mol
-
USE
Topotecan was launched in the US for the second-line treatment of ovarian
cancer. It can be prepared in four steps from camptothecin and is a water soluble
derivative of the natural product with decreased toxicity. Unlike its chemical relative
irinotecan, topotecacan in not a prodrug and does not require bioactivation. It is an
inhibitor of topoisomerase I. Specifically, it inhibits the release of topoisomerase I
from DNA, where it relaxes supercoiled DNA, giving rise to single-strand breaks.
When the replication fork reaches this complex, double-stand breaks can occur. This
signals apoptosis and eventually gives rise to cell death. Evidence indicates
hycamtin is safe for people with impaired hepatic function.
Lastest Price from Topotecan manufacturers
- Topotecan
-
- $65.00 /G
- CAS:123948-87-8
- Min. Order: 1G
- Purity: 99%
- Supply Ability: 10kgs
- 2022-06-06
- Topotecan
-
- $10.00-15.00
- CAS:123948-87-8
- Min. Order: 1KG
- Purity: 99%+ HPLC
- 2021-07-13
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- Company Name:Shanghai Zhen Li Biological Technology Co., Ltd
- Tel:021-16621358918; 18516310516;16621358918;13045646768
- Products Intro:Product Name:Topotecan
CAS:123948-87-8
Purity:99% - CB Index:58
- Related Information:Catalog(19060)
- Company Name:Nanbu County Chengxin Technology Co., Ltd.
- Tel:0838-5675166 15883665058
- Products Intro:Product Name:Topotecan hydrochloride
CAS:123948-87-8
More... - CB Index:55
- Related Information:Catalog(956)
- Company Name:Wuhan EnTai Technology Development Co,.Ltd
- Tel:86-27-82330560
- Products Intro:Product Name:Topotecan
CAS:123948-87-8
More... - CB Index:69
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel: 18930552037
- Products Intro:Product Name:Topotecan
CAS:123948-87-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:Chembest Research Laboratories Limited
- Tel:021-20908456
- Products Intro:Product Name:Topotecan
CAS:123948-87-8
Remarks:C14281 More... - CB Index:61
- Related Information:Catalog(5996)
- Company Name:Beijing Ouhe Technology Co., Ltd
- Tel:13552068683 13522913783
- Products Intro:Product Name:(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
CAS:123948-87-8
Purity:98% Package:1g More... - CB Index:60
- Related Information:Catalog(11775)
- Company Name:Jia Xing Isenchem Co.,Ltd
- Tel:0573-85285100 18627885956
- Products Intro:Product Name:isenchem
CAS:123948-87-8
Purity:98% (HPLC或者GC) Package:25g,100g,500g;1kg More... - CB Index:66
- Related Information:Catalog(9389)
- Company Name:Shanghai Hanhong Scientific Co.,Ltd.
- Tel:021-54306202 13764082696
- Products Intro:Product Name:Topotecan HCl
CAS:123948-87-8
Remarks:E2063 More... - CB Index:64
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