EHT1864
754240-09-0 Basic informationMore
- Product Name:EHT1864
- Synonyms: 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride EHT 1864 2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-4H-pyran-4-one,hydrochloride (1:2) EHT 1864, >=98% 2-(morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one,dihydrochloride CS-1239 CS-1343 EHT-1864;EHT-1864
- CAS:754240-09-0
- MF:C25H27F3N2O4S2HCl
- MW:0
- EINECS:
- Mol File:754240-09-0.mol
-
USE
EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively. It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras. EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation. It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 μM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:EHT 1864;5-(5-(7-(TrifluoroMethyl)quinolin-4-ylthio)pentyloxy)-2-(MorpholinoMethyl)-4H-pyran-4-onedihydrochloride
CAS:754240-09-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15848)
- Company Name:TargetMol Chemicals Inc.
- Tel:021-33632979 15002134094
- Products Intro:Product Name:EHT 1864
CAS:754240-09-0
Package:1 mg;1 mL;10 mg;2 mg;25 mg;5 mg;50 mg Remarks: 90+%，具体纯度信息请见官网 More... - CB Index:58
- Related Information:Catalog(7934)
- Company Name:Shanghai XinKai Chemical Technology Co., Ltd.
- Tel:021-58930698 15921516558
- Products Intro:Product Name:Name
CAS:754240-09-0
Purity:95%-98% Package:1g-1kg More... - CB Index:55
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- Company Name:AdooQ Bioscience CHINA
- Tel:025-58849295 18951903616;
- Products Intro:Product Name:EHT 1864
CAS:754240-09-0
Purity:0.98 Package:1mg;5mg;10mg;25mg;50mg;100mg More... - CB Index:60
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- Company Name:Sigma-Aldrich
- Tel:021-61415566 800-8193336
- Products Intro:Product Name:EHT 1864
CAS:754240-09-0
Purity:>=98% (HPLC) Package:10mg Remarks:E1657 More... - CB Index:80
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