QX 314 chloride
5369-03-9 Basic informationMore
- Product Name:QX 314 chloride
- Synonyms: QX 314 CHLORIDE N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE QX314.Cl 2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride [2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride [2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride Lidocaine N-ethyl chloride
- CAS:5369-03-9
- MF:C16H27ClN2O
- MW:298.85
- EINECS:
- Mol File:5369-03-9.mol
-
USE
<p>QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.</p>
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:QX 314 chloride;N-(2,6-DiMethylphenylcarbaMoylMethyl)triethylaMMoniuMchloride
CAS:5369-03-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:Hangzhou Yuhao Chemical Technology Co., Ltd
- Tel:0571-82693216
- Products Intro:CAS:5369-03-9
More... - CB Index:52
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- Company Name:HangZhou YuHao Chemical Technology Co., Ltd.
- Tel:0571-82693216
- Products Intro:Product Name:QX314.Cl
CAS:5369-03-9
Purity:98% Package:1g; 10g; 100g More... - CB Index:58
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- Company Name:AdooQ Bioscience CHINA
- Tel:025-58849295 18951903616;
- Products Intro:Product Name:QX 314 chloride
CAS:CAS: 5369-03-9
Purity:0.98 Package:1mg;5mg;10mg;25mg;50mg;100mg More... - CB Index:60
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- Company Name:Sigma-Aldrich
- Tel:021-61415566 800-8193336
- Products Intro:Product Name:Lidocaine N-ethyl chloride
CAS:5369-03-9
Package:500mg, 1g Remarks:L1663 More... - CB Index:80
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- Company Name:Beijing Jin Ming Biotechnology Co., Ltd.
- Tel:010-60605840 18892239720
- Products Intro:Product Name:Lidocaine N-ethyl chloride
CAS:5369-03-9
Purity:98% Package:250mg;500mg;1g - CB Index:58
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- Company Name:Capot Chemical Co.,Ltd.
- Tel:571-85586718 +8613336195806
- Products Intro:Product Name:2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride
CAS:5369-03-9
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg More... - CB Index:60
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