Teneligliptin
760937-92-6 Basic informationMore
- Product Name:Teneligliptin
- Synonyms: teneligliptin 3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine Methanone,[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl- Teneligptin WS [(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone API (Teneligliptin free base) Teliglietin Teneligliptin (MP-513)
- CAS:760937-92-6
- MF:C22H30N6OS
- MW:426.58
- EINECS:
- Mol File:760937-92-6.mol
-
USE
Teneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC<sub>50</sub>=0.37 nM).
Lastest Price from Teneligliptin manufacturers
- Teneligliptin
-
- US $0.00-0.00/kg
- CAS:760937-92-6
- Min. Order: 1kg
- Purity: 99%, Single impurity＜0.1
- Supply Ability: 1 ton
- 2024-11-22
- Teneligliptin
-
- US $15.00-10.00/KG
- CAS:760937-92-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-07-13
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Teneligliptin
CAS:760937-92-6
Package:100Mg,250Mg,25Mg More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:Shanghai Hanhong Scientific Co.,Ltd.
- Tel:021-54306202 13764082696
- Products Intro:Product Name:Teneligliptin
CAS:760937-92-6
Purity:98+% Remarks:AB07757 More... - CB Index:64
- Related Information:Catalog(42958)
- Company Name:Daicel Chiral Technologies (China)CO.,LTD
- Tel:021-50460086-9 15921403865
- Products Intro:Product Name:diethylamine hemi((((R)-1-(6-((((9-((R)-2-(phosphonomethoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid
Purity:95% HPLC Package:10MG ;25MG;50MG;100MG Remarks:DCTI-C-1190 - CB Index:65
- Related Information:Catalog(7191)
- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel:400-400-6206333 18521732826
- Products Intro:Product Name:Teneligliptin
CAS:760937-92-6
Purity:98% Package:100mg/RMB 2059.90;25mg/RMB 720.90;500mg/RMB 6797.90 More... - CB Index:65
- Related Information:Catalog(25003)