L-AP4
23052-81-5 Basic informationMore
- Product Name:L-AP4
- Synonyms: L-AP4 L(+)-2-AMINO-4-PHOSPHONOBUTANOIC ACID L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID (L-AP4) L(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID 97% (2S)-2-Amino-4-phosphonobutyric acid (S)-4-Phosphono-2-aminobutanoic acid (S)-4-Phosphono-2-aminobutyric acid
- CAS:23052-81-5
- MF:C4H10NO5P
- MW:183.1
- EINECS:200-258-5
- Mol File:23052-81-5.mol
-
USE
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.
Lastest Price from L-AP4 manufacturers
- L-AP4
-
- US $15.00-10.00/KG
- CAS:23052-81-5
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-08-12
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:L-AP4
CAS:23052-81-5
Purity:>99% Package:10mg, 50mg More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:L-AP4;L-(+)-2-AMino-4-phosphonobutyricacid
CAS:23052-81-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15839)
- Company Name:Shanghai Balmxy Pharmaceutical Co., Ltd
- Tel:021-24206007 13764915196
- Products Intro:Product Name:(S)-2-Amino-4-phosphonobutanoicacid
CAS:23052-81-5
Purity:98%+ Package:5g;25g;100g;500g;1kg;5kg;25kg;100kg Remarks:BX60379 - CB Index:55
- Related Information:Catalog(6773)
- Company Name:Sigma-Aldrich
- Tel:021-61415566 800-8193336
- Products Intro:Product Name:L-(+)-2-Amino-4-phosphonobutyric acid
CAS:23052-81-5
Purity:optical purity optical purity: >=95% (HPLC, Marfey's reagent Package:.5MG Remarks:A7929-.5MG More... - CB Index:80
- Related Information:Catalog(51456)
- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:L-AP4
CAS:23052-81-5
Purity:99% Package:1mg;5mg;10mg More... - CB Index:58
- Related Information:Catalog(9806)