Lomeguatrib
192441-08-0 Basic informationMore
- Product Name:Lomeguatrib
- Synonyms: Lomeguatrib 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine 6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine 6-((4-Bromo-2-thienyl)methoxy)purin-2-amine C521206 2-AMino-6-(4-broMothiophen-2-ylMethoxy)-9H-purine 6-[(4-BroMo-2-thienyl)Methoxy] -1H-purin-2-aMine 6-[(4-BroMo-2-thienyl)Methoxy]-9H-purin-2-aMine
- CAS:192441-08-0
- MF:C10H8BrN5OS
- MW:326.17
- EINECS:
- Mol File:192441-08-0.mol
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USE
O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein which removes an alkyl group from the O6 position on guanine in an autoinactivating reaction. Although important in normal DNA repair, this reaction confers resistance to treatments that use O6-alkylating agents to produce cytotoxicity, e.g., in cancer. Lomeguatrib is a modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM). A non-toxic compound, lomeguatrib completely inactivates MGMT in human prostate and colorectal tumors when given as a single 120 mg oral dose and in primary central nervous system cancers at 160 mg.
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- Company Name:Shanghai Boyle Chemical Co., Ltd.
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- Products Intro:Product Name:Lomeguatrib
CAS:192441-08-0
More... - CB Index:55
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:18210857532 18210857532
- Products Intro:Product Name:LoMeguatrib
CAS:192441-08-0
Package:250Mg,25Mg More... - CB Index:76
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- Company Name:Chemsky (shanghai) International Co.,Ltd
- Tel:021-50135380
- Products Intro:Product Name:LoMeguatrib;6-[(4-BroMo-2-thienyl)Methoxy]-9H-purin-2-aMine; 6-[(4-BroMo-2-thienyl)Methoxy]
-1H-purin-2-aMine; 2-AMino-6-(4-broMothiophen-2-ylMethoxy)-9H-purine; PaTrin 2
CAS:192441-08-0
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg More... - CB Index:60
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- Company Name:Jinan Trio PharmaTech Co., Ltd.
- Tel:0531-88811783
- Products Intro:Product Name:LoMeguatrib
CAS:192441-08-0
Purity:99% Package:5Mg, 10Mg, 20Mg, 50Mg More... - CB Index:62
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- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:Lomeguatrib
CAS:192441-08-0
Purity:>98%,BR Package:50MG Remarks:3670 More... - CB Index:58
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- Company Name:Shanghai T&W Pharmaceutical Co., Ltd.
- Tel:+86 21 61551611
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CAS:192441-08-0
Purity:98% Package:50kg;25kg;10kg;5kg;500g;500mg; More... - CB Index:58
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- Company Name:Haoyuan Chemexpress Co., Ltd.
- Tel:021-58950125
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CAS:192441-08-0
Purity:>98% Package:1255RMB/10mg More... - CB Index:61
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- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel:400-6206333 13167063860
- Products Intro:Product Name:Lomeguatrib
CAS:192441-08-0
Purity:≥98% Package:10mg/RMB 610.90;50mg/RMB 2010.90 More... - CB Index:65
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