MEPERIDINE

• Product Name:MEPERIDINE
• Synonyms: N-Methyl-4-phenyl-4-carbethoxypiperidine Petantin Pethanol Pethidin Pethidine Pethidineter Petydyna Phetidine
• CAS:57-42-1
• MF:C15H21NO2
• MW:247.33
• EINECS:200-329-1
• Mol File:57-42-1.mol
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Meperidine (Demerol) was discovered in 1939 during a serendipitous screening of compounds being studied for antispasmodic activity. Mice given meperidine were noted to carry their tails in an erect position (the Straub tail reaction), which was indicative of narcotic analgesia. This led to the study of meperidine and derivatives as analgesic agents. Meperidine was found to have low potency at the receptor compared with morphine (0.2%) but much higher penetration into the brain resulting in a compound with about 10% of the potency of morphine.<br/>Structural changes that increase the potency of meperidine include the introduction of an mhydroxyl on the phenyl ring, substituting the methyl on the N for a phenylethyl or a p-aminophenylethyl. Replacing the N-methyl with an N-allyl or N-cyclopropylmethyl group does not generate an antagonist, unlike the similar substitution of the morphine congeners. Meperidine quickly penetrates the blood-brain barrier and thus has a quick onset of activity and a high abuse potential.