Cercosporamide
131436-22-1 Basic informationMore
- Product Name:Cercosporamide
- Synonyms: Cercosporamide (R)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9aβ-methyl-9-oxodibenzofuran-4-carboxamide 4-Dibenzofurancarboxamide Cercosporamide from Cercosporidium henningsii (9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide (-)-CERCOSPORAMIDE Cercosporamide ((-)-Cercosporamide) 4-Dibenzofurancarboxamide, 8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-, (9aS)-
- CAS:131436-22-1
- MF:C16H13NO7
- MW:331.28
- EINECS:
- Mol File:131436-22-1.mol
-
USE
Cercosporamide is a natural antifungal phytotoxin isolated from the Cercosporidium fungus, which infects the leaves of cassava plants. Its antifungal effect results from its selective and potent inhibition of fungal PKC-like 1 kinases (Pkc1), which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1). Cercosporamide less effectively inhibits human PKC isoforms PKCα, β, and γ (IC50s = 1.02, 0.35, and 5.8 μM, respectively), an action linked to lowering of plasma glucose in hyperglycemic mice. However, it potently inhibits MAPK-interacting kinases Mnk1 and Mnk2 (IC50 = 115 and 11 nM, respectively), reducing protein translation in cancer cells. Cercosporamide is orally bioavailable.
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:CercosporaMide
CAS:131436-22-1
Package:10Mg,1Mg More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:Guangzhou Isun Pharmaceutical Co., Ltd
- Tel:020-39119399 18927568969
- Products Intro:Product Name:Cercosporamide from Cercosporidium henningsii
CAS:131436-22-1
Purity:98% (HPLC) Package:5MG; 25MG; 100MG; 1G More... - CB Index:55
- Related Information:Catalog(4428)
- Company Name:Sigma-Aldrich
- Tel:021-61415566 800-8193336
- Products Intro:Product Name:Cercosporamide
CAS:131436-22-1
Purity:>=98% (HPLC) Package:500μg Remarks:SML0172 More... - CB Index:80
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- Company Name:Beijing Jin Ming Biotechnology Co., Ltd.
- Tel:010-60605840 18892239720
- Products Intro:Product Name:Cercosporamide
CAS:131436-22-1
Purity:98% Package:500ug - CB Index:58
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- Company Name:Lynnchem
- Tel:86-(0)29-85992781 17792393971
- Products Intro:Product Name:Cercosporamide
CAS:131436-22-1
Purity:>95% by HPLC Package:1mg;5mg More... - CB Index:58
- Related Information:Catalog(4587)
- Company Name:Shenzhen Polymeri Biochemical Technology Co., Ltd.
- Tel:+86-400-002-6226 +86-13028896684;
- Products Intro:Product Name:CercosporaMide
CAS:131436-22-1
More... - CB Index:58
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