CDK1/2InhibitorIII
443798-55-8 Basic informationMore
- Product Name:CDK1/2InhibitorIII
- Synonyms: CDK1/2InhibitorIII 5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide 2 Inhibitor III Cdk-1/2 Inhibitor III,Cdk1/2 Inhibitor III 1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-
- CAS:443798-55-8
- MF:C15H13F2N7O2S2
- MW:425.44
- EINECS:
- Mol File:443798-55-8.mol
-
USE
Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/2 Inhibitor III is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50s = 0.6 and 0.5 nM, respectively). It less potently inhibits CDC2-like kinases 1 and 3, VEGFR2, and GSK-3β (IC50s = 8.9, 29, 32, and 140 nM, respectively) and is without effect against a panel of other kinases. Cdk1/2 Inhibitor III blocks the growth of several cancer cell lines (IC50 values range from 20 to 92 nM).
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- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:CDK 1/2 Inhibitor III
CAS:443798-55-8
Purity:95.00% Package:1mg;5mg;10mg - CB Index:58
- Related Information:Catalog(9803)
- Company Name:DC Chemicals
- Tel:021-58447131 13564518121
- Products Intro:Product Name:Cdk1/2 Inhibitor III
CAS:443798-55-8
Purity:98% HPLC Package:100mg，250mg，1g - CB Index:58
- Related Information:Catalog(9409)
- Company Name:cjbscvictory
- Tel:13348960310 13348960310
- Products Intro:Product Name:2 Inhibitor III
CAS:443798-55-8
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg - CB Index:58
- Related Information:Catalog(10524)
- Company Name:TargetMol Chemicals Inc.
- Tel: 4008200310
- Products Intro:Product Name:Cdk1/2 Inhibitor III
CAS:443798-55-8
Purity:100% Package:1mg/RMB 2350;5mg/RMB 5630;10mg/RMB 7790 - CB Index:58
- Related Information:Catalog(24641)
- Company Name:Nantong Hanfang Biotechnology Co. , Ltd.
- Tel:hanfangpharma@126.com; 18616537568
- Products Intro:Product Name:CDK1/2InhibitorIII
CAS:443798-55-8
Purity:98%+ Package:1g；5g；10g；100g; 1kg - CB Index:58
- Related Information:Catalog(29981)
- Company Name:Sangon Biotech (Shanghai) Co.,Ltd.
- Tel:400-821-026
- Products Intro:Product Name:Cdk1/2 Inhibitor III
CAS:443798-55-8
- CB Index:58
- Related Information:Catalog(47255)
- Company Name:Cayman Chemical Company
- Tel:800-3649897
- Products Intro:Product Name:Cdk1/2 Inhibitor III
- CB Index:58
- Related Information:Catalog(21643)