PLERIXAFOR
110078-46-1 Basic informationMore
- Product Name:PLERIXAFOR
- Synonyms: 1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane 1,4,8,11-Tetraazacyclotetradecane, 1,1'-(1,4-phenylenebis(methylene))bis- Mozobil Sdz sid 791 Unii-S915p5499n 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Plerixafor(AMD3100) 1-{[4-(1,4,8,11-tetraazacyclotetradecan-1-ylMethyl)phenyl]Methyl}-1,4,8,11-tetraazacyclotetradecane
- CAS:110078-46-1
- MF:C28H54N8
- MW:502.78
- EINECS:1592732-453-0
- Mol File:110078-46-1.mol
-
USE
Plerixafor inhibits CXCL12-mediated chemotaxis with a potency lightly better than its affinity for CXCR4. Plerixafor also antagonizes SDF-1/CXCL12 ligand binding with an IC50 of 651 nM. Plerixafor inhibits SDF-1 mediated GTP-binding, SDF-1 mediated calcium flux and SDF-1 stimulated chemotaxis with IC50 of 27 nM, 572 nM and 51 nM, respectively. Plerixafor does not inhibit calcium flux against cells expressing CXCR3, CCR1, CCR2b, CCR4, CCR5 or CCR7 when stimulated with their cognate ligands, nor does Plerixafor inhibit receptor binding of LTB4. Plerixafor does not, on its own, induce a calcium flux in the CCRF–CEM cells, which express multiple GPCRs including CXCR4, CCR4 and CCR7.
Lastest Price from PLERIXAFOR manufacturers
- Plerixafor
-
- US $921.60 /g/Bag
- CAS:110078-46-1
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 5KG
- 2023-11-13
- Plerixafor
-
- US $50.00 /kg
- CAS:110078-46-1
- Min. Order: 1kg
- Purity: 99.9%
- Supply Ability: 10000tons
- 2023-08-22
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- Company Name:Hubei Changrun Biomedical Technology Co., Ltd.
- Tel:027-63496417 13007129042
- Products Intro:Product Name:PLERIXAFOR
CAS:110078-46-1
Purity:99% Package:1g/袋/RMB 400;10g/袋 - CB Index:58
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- Company Name:Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
- Tel:+86-027-59232304 15387063101
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CAS:110078-46-1
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- Company Name:ShangHai Biochempartner Co.,Ltd
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Purity:98% HPLC LCMS Package:100mg;500mg;1g;5g;10g More... - CB Index:62
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- Company Name:Shanghai jerryxing Biomedical Technology Co., Ltd
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Purity:98% HPLC Package:500mg;1g;10g;100g;1kg - CB Index:58
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- Company Name:Wuhan Sunrise Technology Development Co., Ltd.
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CAS:110078-46-1
Purity:99 Package:20g Remarks:used for research only More... - CB Index:62
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- Company Name:J & K SCIENTIFIC LTD.
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- Products Intro:Product Name:Plerixafor, 99%
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- Company Name:Chemvon Biotechnology Co., Ltd
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CAS:110078-46-1
Purity:98% Package:1g, 10g, 100g, 200g, 1kg, 5kg More... - CB Index:57
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