RG108
48208-26-0 Basic informationMore
- Product Name:RG108
- Synonyms: (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid RG108/RG-108 (S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid N-Phthaloyl-L-tryptophan 1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)- N-Phthaloyl-L-tryptophan (S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid DNA Methyltransferase Inhibitor N-Phthalyl-L-tryptophan
- CAS:48208-26-0
- MF:C19H14N2O4
- MW:334.33
- EINECS:
- Mol File:48208-26-0.mol
-
USE
DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:N-Phthalyl-L-tryptophan
CAS:48208-26-0
Purity:98.0%(LC&T) Package:200MG,50MG More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:RG 108;N-Phthalyl-L-tryptophan
CAS:48208-26-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15839)
- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:N-Phthalyl-L-tryptophan
CAS:48208-26-0
Purity:98.0% LC&T Package:200MG,50MG More... - CB Index:81
- Related Information:Catalog(24529)
- Company Name:Shandong Xiya Chemical Co., Ltd
- Tel:4009903999 13355009207
- Products Intro:CAS:48208-26-0
Purity:>=98.0% Package:10mg;250mg;50mg - CB Index:57
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- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:RG108
CAS:48208-26-0
Purity:>98%,DNA methyltransferase Package:50MG More... - CB Index:58
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- Company Name:Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
- Tel:025-66099280 17798518460
- Products Intro:Product Name:RG108
CAS:48208-26-0
Purity:95% Package:1g;5g;10g More... - CB Index:55
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