Tofacitinib

• Product Name:Tofacitinib
• Synonyms: 3-((3R,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)-2-oxopiperidin-1-yl)propanenitrile Tropsch iMatinib CP 690550 3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (3R,4R)-4-methyl-3-(methyl-1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile Tofacitinib,CP-690550 Tofacitinib, >=98% 3-[4(R)-Methyl-3(R)-[N-methyl-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]- 3-oxopropanenitrile (3R,4R)-4-methyl-3-(methyl-1H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-2-piperidinepropanenitrile
• CAS:477600-75-2
• MF:C16H20N6O
• MW:312.38
• EINECS:689-145-4
• Mol File:477600-75-2.mol
• 

In November 2012, the US FDA approved tofacitinib (also referred to as CP-690550) for the treatment of adult patients with moderate to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to methotrexate. Tofacitinib is the first small molecule kinase inhibitor approved for the treatment of RA. Tofacitinib is an inhibitor of the four subtypes of Janus kinase (JAK): JAK1, JAK2, JAK3, and Tyk2. The JAKs are intracellular, nonreceptor tyrosine kinases that play important roles in the signal transduction pathway of many cytokines (e.g., interleukins 2, 4, 7, 9, 15, and 21) and are involved in the propagation of inflammation in RA. Tofacitinib acts by inhibiting the phosphorylation and activation of signal transducers and activators of transcription (STATs), thereby suppressing the production of inflammatory mediators in joint tissue. At the enzyme level, tofacitinib inhibits JAKs 1, 2, 3, and Tyk2 with IC_50s of 3.2, 4.1, 1.6, and 34 nM, respectively. At the cellular level, tofacitinib inhibits the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC_50s of 406, 56, and 1377 nM, respectively.

• Tofacitinib
• 
• US $0.00-0.00/g
• CAS:477600-75-2
• Min. Order: 10g
• Purity: 99% HPLC
• Supply Ability: 10000
• 2024-12-18

• Tofacitinib
• 
• US $150.00 /kg
• CAS:477600-75-2
• Min. Order: 1kg
• Purity: 99%
• Supply Ability: 500kg
• 2024-12-18

• Company Name:Shanghai Boc Chemical Co.,Ltd
• Tel:021-34975603-808 18721111801
• Products Intro:Product Name:3-((3R,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile
  CAS:477600-75-2
  Purity:99.5% EE:99.5% Package:100g,500g,1kg,5kg More...
• CB Index:64
• Related Information:Catalog(997)

• Company Name:Zhuhai Yourun Co., Ltd.
• Tel:0756-6811852 13923369215
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  CAS:477600-75-2
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• Company Name:Shanghai Mixiu Chemical Co., Ltd.
• Tel: 18101936766
• Products Intro:Product Name:Tofacitinib
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• Company Name:Junyu Chemexpress Co., Ltd.
• Tel:0731-88036271 13723890100
• Products Intro:Product Name:Tofacitinib
  CAS:477600-75-2
  Purity:99.50% Package:1g,25g,50g,100g,200g,500g,1kg,5kg More...
• CB Index:58
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• Company Name:Hebei Chenguang Tianrun Pharma Co., Ltd.
• Tel:0310-2816865 15175172220
• Products Intro:Product Name:Tofacitinib;3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile;
  CAS:477600-75-2
  Purity:99% HPLC Package:50G;20G;10G
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• Company Name:J & K SCIENTIFIC LTD.
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• Company Name:Chembest Research Laboratories Limited
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• Products Intro:Product Name:Tofacitinib(CP-690550)
  CAS:477600-75-2
  Purity:99% Package:50mg;100mg;500mg;1g;5g;10g;50g;100g;500g Remarks:C13502 More...
• CB Index:61
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