Alsterpaullone
237430-03-4 Basic informationMore
- Product Name:Alsterpaullone
- Synonyms: ALSTERPAULLONE 9-NITRO-7,12-DIHYDROINDOLO-[3,2-D][1]BENZAZEPIN-6(5H)-ONE 9-NITRO-7,12-DIHYDROINDOLO-[3,2-D][1]BENZAZEPIN-6(5)-ONE 9-nitro-7,12-dihydrobenzo[2,3]azepino[4,5-b]indol-6(5H)-one 9-Nitropaullone NSC 705701 Alsterpaullone (9-Nitropaullone ALSTERPAULLONE (9-NITROPAULLONE;NSC 705701)
- CAS:237430-03-4
- MF:C16H11N3O3
- MW:293.28
- EINECS:
- Mol File:237430-03-4.mol
-
USE
Alsterpaullone is a derivative of kenpaullone , an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β). With slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Alsterpaullone has been used to inhibit the cytosolic degradation of β-catenin to alter the canonical Wnt signaling pathway in primary axis patterning, to reduce tau phosphorylation in an effort to modify neuropathological events associated with Alzheimer’s disease, and to alter cell proliferation or protein expression in various diseases.
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- Company Name:J & K SCIENTIFIC LTD.
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- Products Intro:Product Name:Alsterpaullone
CAS:237430-03-4
Package:10Mg,2.5Mg,25Mg More... - CB Index:76
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- Company Name:Guangzhou Isun Pharmaceutical Co., Ltd
- Tel:020-39119399 18927568969
- Products Intro:Product Name:Alsterpaullone
CAS:237430-03-4
Purity:>=98% (HPLC), powder Package:25Mg; 1g; 100g; 500g More... - CB Index:55
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- Company Name:Sigma-Aldrich
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- Products Intro:Product Name:Alsterpaullone
CAS:237430-03-4
Purity:>=98% (HPLC), powder Package:1MG Remarks:A4847-1MG More... - CB Index:80
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- Company Name:Tcichem, Inc.
- Tel: 13918644899
- Products Intro:Product Name:ALSTERPAULLONE
CAS:237430-03-4
Purity:95% HPLC Package:1G;5G;10G;25G;50G;100G;1KG More... - CB Index:55
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- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:Alsterpaullone
CAS:237430-03-4
Purity:98% Package:1mg;5mg;10mg - CB Index:58
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- Company Name:ShangHai Biochempartner Co.,Ltd
- Tel:177-54423994 17754423994
- Products Intro:Product Name:Alsterpaullone
CAS:237430-03-4
Purity:98% HPLC LCMS Package:500mg;1g;10g - CB Index:62
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- Company Name:Shanghai SuperLan Chemcial Technique Centre
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- Products Intro:CAS:237430-03-4
Purity:95% Package:1G,5G,10G,50G,100G,1KG More... - CB Index:58
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