LOXAPINE
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A dibenzoxazepine derivative in use is loxapinesuccinate, 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f ][1,4]oxazepine succinate (Daxolin). The structural relationshipto the phenothiazine antipsychotics is apparent. Examplesin this group are clothiapine, metiapine, zotepine, and others.They have electron-withdrawing groups at position 2, relativelyclose to the side-chain nitrogen atoms. Loxapine, an effectiveantipsychotic, blocks D<sub>2</sub>-type receptors and has side effectssimilar to those reported for the phenothiazines. Itsmetabolism involves aromatic hydroxylation to give severalphenolic metabolites that have higher affinity for D2 receptorsthan the parent. It is also N-demethylated to yield amoxapine(an antidepressant drug), which inhibits norepinephrine (NE)neurotransporter to block neuronal NE reuptake.
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- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel:400-400-6206333 18521732826
- Products Intro:Product Name:Loxapine
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- Company Name:Baoji Guokang Bio-Technology Co., Ltd.
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- Company Name:Nanjing Shizhou Biology Technology Co.,Ltd
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- Products Intro:Product Name:Loxapine
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- Company Name:Shanghai Qiming Biological Technology Co., Ltd.
- Tel:021-61483491
- Products Intro:Product Name:Loxapine
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- Company Name:Jiangxi Jianglan Pure Biological Reagent Co., Ltd.
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- Company Name:Shanghai Weiwei Biological Technology Co., Ltd.
- Tel:021-55669583 18616258598
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- Company Name:Jin Clone (Beijing) Biotechnology Co., Ltd.
- Tel:400-910-1997 13341102640
- Products Intro:Product Name:Loxapine
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- Company Name:Shanghai Machine Pure Industrial Co., Ltd.
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