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is well tolerated in the dilutions normally employed on the skin and mucous membranes. However, benzalkonium chloride has been associated with adverse effects when used in some pharmaceutical formulations.<br/> Ototoxicity can occur when benzalkonium chloride is applied to the ear and prolonged contact with the skin can occasionally cause irritation and hypersensitivity. Benzalkonium chloride is also known to cause bronchoconstriction in some asthmatics when used in nebulizer solutions.<br/> Toxicity experiments with rabbits have shown benzalkonium chloride to be harmful to the eye in concentrations higher than that normally used as a preservative. However, the human eye appears to be less affected than the rabbit eye and many ophthalmic products have been formulated with benzalkonium chloride 0.01% w/v as the preservative.<br/> Benzalkonium chloride is not suitable for use as a preservative in solutions used for storing and washing hydrophilic soft contact lenses, as the benzalkonium chloride can bind to the lenses and may later produce ocular toxicity when the lenses are worn. Solutions stronger than 0.03% w/v concentration entering the eye require prompt medical attention.<br/> Local irritation of the throat, esophagus, stomach, and intestine can occur following contact with strong solutions (>0.1% w/v). The fatal oral dose of benzalkonium chloride in humans is estimated to be 1–3 g. Adverse effects following oral ingestion include vomiting, collapse, and coma. Toxic doses lead to paralysis of the respiratory muscles, dyspnea, and cyanosis.<br/> LD<sub>50</sub> (mouse, oral): 150 mg/kg<br/> LD<sub>50</sub> (rat, IP): 14.5 mg/kg<br/> LD<sub>50</sub> (rat, IV): 13.9 mg/kg<br/> LD<sub>50</sub> (rat, oral): 300 mg/kg<br/> LD<sub>50</sub> (rat, skin): 1.42 g/kg
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  • Benzalkonium chloride
  • US $82.00 /KG
  • CAS:8001-54-5
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 20tons
  • 2019-10-23

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