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532-32-1

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532-32-1 Basic informationMore
USE
Ingested sodium benzoate is conjugated with glycine in the liver to yield hippuric acid, which is excreted in the urine. Symptoms of systemic benzoate toxicity resemble those of salicylates. Whereas oral administration of the free-acid form may cause severe gastric irritation, benzoate salts are well tolerated in large quantities: e.g. 6 g of sodium benzoate in 200mL of water is administered orally as a liver function test.<br/> Clinical data have indicated that sodium benzoate can produce nonimmunological contact urtcaria and nonimmunological immediate contact reactions. However, it is also recognized that these reactions are strictly cutaneous, and sodium benzoate can therefore be used safely at concentrations up to 5%. However, this nonimmunological phenomenon should be considered when designing formulations for infants and children.<br/> Other adverse effects include anaphylaxis and urticarial reactions, although a controlled study has shown that the incidence of urticaria in patients given benzoic acid is no greater than that with a lactose placebo.<br/> It has been recommended that caffeine and sodium benzoate injection should not be used in neonates; however, sodium benzoate has been used by others in the treatment of some neonatal metabolic disorders. It has been suggested that there is a general adverse effect of benzoate preservatives on the behavior of 3-yearold children, which is detectable by parents, but not by a simple clinical assessment.<br/> The WHO acceptable daily intake of total benzoates, calculated as benzoic acid, has been estimated at up to 5 mg/kg of bodyweight.<br/> LD50 (mouse, IM): 2.3 g/kg<br/> LD50 (mouse, IV): 1.4 g/kg<br/> LD50 (mouse, oral): 1.6 g/kg<br/> LD50 (rabbit, oral): 2.0 g/kg<br/> LD50 (rat, IV): 1.7 mg/kg<br/> LD50 (rat, oral): 4.1 g/kg
Lastest Price from Sodium benzoate manufacturers
  • Sodium benzoate
  • US $1100.00 /T
  • CAS:532-32-1
  • Min. Order: 25KG
  • Purity: 99%
  • Supply Ability: 20 tons
  • 2021-10-14
  • Sodium benzoate
  • US $1250.00 /KG
  • CAS:532-32-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100TONS
  • 2021-09-14

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  • Company Name:-Tenglong Company
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  • CB Index:58
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  • Products Intro:Product Name:Soudium benzoate
    CAS:532-32-1
    Purity:药用辅料 99% Package:250g;15kg;135kg Remarks:http://www.nj-reagent.com/item/detail/C01317550.htm
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