BAY 11-7085
196309-76-9 Basic informationMore
- Product Name:BAY 11-7085
- Synonyms: BAY 117083 (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile (2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE (E)-3-(T-BUTYLPHENYLSULFONYL)-2-PROPENENITRILE (E)3-[(4-T-BUTYLPHENYL)SULFONYL]-2-PROPENENITRILE BAY 11-7085 (E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile BAY 117083 (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile BAY 11-7085
- CAS:196309-76-9
- MF:C13H15NO2S
- MW:249.33
- EINECS:
- Mol File:196309-76-9.mol
-
USE
In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import. BAY-11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY-11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:Bay 11-7085;(2E)-3-[[4-(1,1-DiMethylethyl)phenyl]sulfonyl]-2-propenenitrile
CAS:196309-76-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15839)
- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
CAS:196309-76-9
Purity:98% HPLC Package:5mg;10mg;50mg;100mg Remarks:Biochemical Reagents; Pharmaceutical Intermediates More... - CB Index:61
- Related Information:Catalog(6005)
- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:BAY 11-7085
CAS:196309-76-9
Purity:97.0% N Package:100MG,10MG More... - CB Index:81
- Related Information:Catalog(24529)
- Company Name:Tetranov Biopharm
- Tel: 13526569071
- Products Intro:Product Name:(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile
CAS:196309-76-9
Purity:95% Package:1g;5g;25g;100g More... - CB Index:64
- Related Information:Catalog(7906)
- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:BAY11-7085
CAS:196309-76-9
Purity:>98%,BR Package:10MG;50MG; Remarks:MB5336 - CB Index:58
- Related Information:Catalog(4727)
- Company Name:Bide Pharmatech Ltd.
- Tel:400-164-7117 13681763483
- Products Intro:Product Name:BAY 11-7085
CAS:196309-76-9
Purity:98% Package:5mg;10mg;25mg;50mg; Remarks:BD252178 - CB Index:60
- Related Information:Catalog(41462)