IMD-0354
978-62-1 Basic informationMore
- Product Name:IMD-0354
- Synonyms: Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy- N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide IMD0354 IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem IKK-2 INHIBITOR V; IMD 0354;IMD0354; IMD-0354, 99%, a synthetic selective NF-kB inhibitor IMD 0354;IMD-0354 IMD-0354 USP/EP/BP IMD0354,IκB kinase,Inhibitor,I kappa B kinase,IKK,inhibit,IMD-0354
- CAS:978-62-1
- MF:C15H8ClF6NO2
- MW:383.67
- EINECS:
- Mol File:978-62-1.mol
-
USE
IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury. IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis. It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 μM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:IMD 0354;N-[3,5-Bis(trifluoroMethyl)phenyl]-5-chloro-2-hydroxybenzaMide
CAS:978-62-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15839)
- Company Name:Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
- Tel:21-57721279
- Products Intro:Product Name:N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide
CAS:978-62-1
Purity:98% Package:1g,10g，100g，1kg - CB Index:56
- Related Information:Catalog(990)
- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:IMD-0354
CAS:978-62-1
Purity:>98%,IKKβ Package:50MG More... - CB Index:58
- Related Information:Catalog(4727)
- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel:400-400-6206333 18521732826
- Products Intro:Product Name:IMD 0354
CAS:978-62-1
Purity:>=99% Package:10mg/RMB 205.90;50mg/RMB 679.90;5mg/RMB 144.90 More... - CB Index:65
- Related Information:Catalog(25003)
- Company Name:Guangzhou Isun Pharmaceutical Co., Ltd
- Tel:020-39119399 18927568969
- Products Intro:Product Name:IMD-0354
CAS:978-62-1
Purity:>=98% (HPLC), solid Package:25Mg; 1g; 100g; 500g More... - CB Index:55
- Related Information:Catalog(4674)