Troglitazone
97322-87-7 Basic informationMore
- Product Name:Troglitazone
- Synonyms: Troglitazone(CS-045) RESULIN(TM) ROMGLIZONE 5-(4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2 ci991 enzopyran-2-yl)methoxy)phenyl)methyl)- gr92132x rezulin
- CAS:97322-87-7
- MF:C24H27NO5S
- MW:441.54
- EINECS:
- Mol File:97322-87-7.mol
-
USE
Troglitazone is a TZD which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes, under the trade name Resulin?, but was withdrawn from the market due to hepatotoxicity. Troglitazone is a potent and selective PPARγ agonist. The EC50 values for transactivation of human and mouse PPARγ in a cell-based assay are 0.55 and 0.78 μM, respectively. In the same assay system, no activation of PPARα and PPARδ was observed at concentrations up to 10 μM. Troglitazone binds to the PPARγ ligand-binding domain (LBD) but fails to induce interaction of the PPARγ LBD with the transcriptional coactivators SRC-1, TIF2, AIB1, p300, or TRAP220. Troglitazone also induces cell cycle arrest and apoptosis in several cancer cell lines with an EC50 of 10 μM.
Lastest Price from Troglitazone manufacturers
- Troglitazone
-
- US $39.00 /KG
- CAS:97322-87-7
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 500000kgs
- 2021-08-13
- Troglitazone
-
- US $15.00-10.00/KG
- CAS:97322-87-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-08-12
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- Company Name:Hangzhou ChangCun Biotechnology Co., Ltd.
- Tel:0571-; 13567100326
- Products Intro:Product Name:Troglitazone
CAS:97322-87-7
Purity:98%HPLC Package:100MG/1G/5G/10G More... - CB Index:50
- Related Information:Catalog(108)
- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Troglitazone
CAS:97322-87-7
Package:100Mg,10Mg More... - CB Index:76
- Related Information:Catalog(94657)
- Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel:021-61259108 18621169109
- Products Intro:Product Name:Troglitazone
CAS:97322-87-7
More... - CB Index:62
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:Troglitazone;5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetraMethyl-2H-1-benzopyran-2-yl)Methoxy]phenyl]Methyl]-2,4-thiazolidinedione
CAS:97322-87-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15839)
- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:Troglitazone(Rezulin)
CAS:97322-87-7
Remarks:C14298 More... - CB Index:61
- Related Information:Catalog(6005)