1-METHYL-D-TRYPTOPHAN

• Product Name:1-METHYL-D-TRYPTOPHAN
• Synonyms: 1-METHYL-D-TRYPTOPHAN 1-Methyl-D-tryptophane 1-METHYL-D-TRYPTOPHAN 95% (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid IndoxiMod Indoximod (NLG-8189） NLG-8189 1-Me-D-Trp
• CAS:110117-83-4
• MF:C12H14N2O2
• MW:218.25
• EINECS:
• Mol File:110117-83-4.mol
• 

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.

• 1-Methyl-D-tryptophan
• 
• US $0.00 /Kg/Drum
• CAS:110117-83-4
• Min. Order: 1KG
• Purity: 98%min
• Supply Ability: 500kg
• 2024-11-21

• 1-Methyl-D-tryptophan 95%
• 
• US $15.00-10.00/KG
• CAS:110117-83-4
• Min. Order: 1KG
• Purity: 99%+ HPLC
• Supply Ability: Monthly supply of 1 ton
• 2021-07-02

• Company Name:Binhai gill polypeptide co. LTD
• Tel:021-61263389 13524856427
• Products Intro:Product Name:1-Methyl-D-tryptophan
  CAS:110117-83-4
  Purity:98% Package:g;kg More...
• CB Index:58
• Related Information:Catalog(9976)

• Company Name:Shanghai Topbiochem Technology Co., Ltd
• Tel:021-58170097
• Products Intro:Product Name:1-METHYL-D-TRYPTOPHAN
  CAS:110117-83-4
  Purity:97% Package:25g;100g;500g;1kg
• CB Index:58
• Related Information:Catalog(9459)

• Company Name:Energy Chemical
• Tel:021-021-58432009 400-005-6266
• Products Intro:Product Name:1-methyl-D-tryptophan
  CAS:110117-83-4
  Purity:98% Package:10g;100g;1kg Remarks:NULL More...
• CB Index:61
• Related Information:Catalog(44689)

• Company Name:Shanghai Hanhong Scientific Co.,Ltd.
• Tel:021-54306202 13764082696
• Products Intro:Product Name:1-Methyl-D-Tryptophan
  CAS:110117-83-4
  More...
• CB Index:64
• Related Information:Catalog(42958)

• Company Name:Dalian Meilun Biotech Co., Ltd.
• Tel:0411-62910999 13889544652
• Products Intro:Product Name:Indoximod (NLG-8189）
  CAS:110117-83-4
  Purity:>98%,BR Package:50MG Remarks:MB3834
• CB Index:58
• Related Information:Catalog(4727)