1-METHYL-D-TRYPTOPHAN
110117-83-4 Basic informationMore
- Product Name:1-METHYL-D-TRYPTOPHAN
- Synonyms: 1-METHYL-D-TRYPTOPHAN 1-Methyl-D-tryptophane 1-METHYL-D-TRYPTOPHAN 95% (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid Indoximod (NLG-8189） NLG-8189 1-Me-D-Trp D-Trp(Me)-OH
- CAS:110117-83-4
- MF:C12H14N2O2
- MW:218.25
- EINECS:
- Mol File:110117-83-4.mol
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USE
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.
Lastest Price from 1-METHYL-D-TRYPTOPHAN manufacturers
- 1-Methyl-D-tryptophan
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- CAS:110117-83-4
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 500kg
- 2025-04-21
- 1-Methyl-D-tryptophan 95%
-
- $10.00-15.00
- CAS:110117-83-4
- Min. Order: 1KG
- Purity: 99%+ HPLC
- 2021-07-02
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- Products Intro:Product Name:1-methyl-D-tryptophan
CAS:110117-83-4
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg More... - CB Index:60
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CAS:110117-83-4
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CAS:110117-83-4
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CAS:110117-83-4
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CAS:110117-83-4
Purity:0.97 Package:mgs,gs,kgs Remarks:A802144 - CB Index:58
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