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BuforMin Hydrochloride

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Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis. Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production via the complex I flavin. Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.<p>BuforMin Hydrochloride is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. BuforMin Hydrochloride has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.</p>
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  • Company Name:CONIER CHEM AND PHARMA LIMITED
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  • Products Intro:Product Name:buformin hydrochloride
    CAS:1190-53-0
    Purity:99% Package:1kg
  • CB Index:58
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  • Company Name:career henan chemical co
  • Tel:+86-0371-86658258
  • Products Intro:Product Name:Buformin Hydrochloride
    CAS:1190-53-0
    Purity:>98% Package:1KG;9.8USD
  • CB Index:58
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  • Company Name:Shaanxi Dideu Medichem Co. Ltd
  • Tel:+86-29-81139210
  • Products Intro:Product Name:BuforMin Hydrochloride USP/EP/BP
    CAS:1190-53-0
    Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
  • CB Index:58
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  • Company Name:Shanghai Acmec Biochemical Technology Co., Ltd.
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  • Products Intro:Product Name:Butyl-Biguanide Hydrochloride
    CAS:1190-53-0
    Purity:分析对照品,Purity>=95% Package:50mg
  • CB Index:58
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  • Company Name:SHANGHAI KEAN TECHNOLOGY CO., LTD.
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  • Products Intro:Product Name:Butyl-Biguanide Hydrochloride
    CAS:1190-53-0
    Purity:0.99 Package:100g;1kg;5KG;1KG
  • CB Index:58
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  • Company Name:DAYANG CHEM (HANGZHOU) CO.,LTD
  • Tel:+86-88938639
  • Products Intro:Product Name:Buformine hydrochloride
    CAS:1190-53-0
    Purity:0.95&0.99 Package:0.1KG;1KG;1000KG Remarks:Hot sales
  • CB Index:58
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  • Company Name:Amadis Chemical Company Limited
  • Tel:571-89925085
  • Products Intro:Product Name:Buformine HCl
    CAS:1190-53-0
    Purity:0.97 Package:mgs,gs,kgs Remarks:A910589
  • CB Index:58
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  • Company Name:Henan Rane Chemical Co., Ltd.
  • Tel:+86-18738066252;
  • Products Intro:Product Name:2-butyl-1-(diaminomethylidene)guanidine;hydrochloride
    CAS:1190-53-0
    Purity:0.98
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