Pirinixic Acid Aminothiazole
1492060-44-2 Basic informationMore
- Product Name:Pirinixic Acid Aminothiazole
- Synonyms: Pirinixic Acid Aminothiazole Pirinixic Acid Aminothiazole Exclusive BADFIDKPYNKNRT-UHFFFAOYSA-N Octanoic acid, 2-[[4-chloro-6-[[4-(2-naphthalenyl)-2-thiazolyl]amino]-2-pyrimidinyl]thio]-
- CAS:1492060-44-2
- MF:C25H25ClN4O2S2
- MW:513.07
- EINECS:
- Mol File:1492060-44-2.mol
-
USE
Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer. Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 μM, respectively). It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms. Pirinixic acid aminothiazole reduces the synthesis of PGE2 and LTC4 during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.[Cayman Chemical]
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- Company Name:MedBioPharmaceutical Technology Inc
- Tel:021-69568360 18916172912
- Products Intro:Product Name:Pirinixic Acid Aminothiazole
CAS:1492060-44-2
Purity:98% Package:1mg; 25mg; 5mg; 10mg Remarks:Medbio - CB Index:58
- Related Information:Catalog(8140)
- Company Name:Nanjing Tengyi Biotechnology Co., Ltd
- Tel:025-58851786 17714337195
- Products Intro:Product Name:Pirinixic Acid Aminothiazole
CAS:1492060-44-2
Purity:95+% Package:1g;5g - CB Index:58
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- Company Name:Shanghai Yifei Biotechnology Co. , Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:Pirinixic Acid Aminothiazole Exclusive
CAS:1492060-44-2
Purity:98% Package:1mg;5mg;10mg - CB Index:58
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- Company Name:Shanghai Benrui Biotechnology Co., Ltd.
- Tel: 13917534498
- Products Intro:Product Name:Pirinixic Acid Aminothiazole
CAS:1492060-44-2
- CB Index:58
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- Company Name:Shanghai Weiwei Biological Technology Co., Ltd.
- Tel:021-55669583 18616258598
- Products Intro:Product Name:Pirinixic Acid Aminothiazole
CAS:1492060-44-2
- CB Index:58
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- Company Name:Absin Bioscience Inc.
- Tel:021-38015121
- Products Intro:Product Name:Pirinixic Acid Aminothiazole
CAS:1492060-44-2
- CB Index:58
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