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Fenfluramine hydrochloride

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USE
Fenfluramine hydrochloride, (±)N-ethyl- -methyl-m-(trifluoromethyl)phenethylamine hydrochloride (Pondimin), isunique in this group of drugs, in that it tends to produce sedationrather than excitation. Effects are said to be mediatedprincipally by central serotoninergic, rather than central noradrenergic,mechanisms. In large doses in experimental animals,the drug is a serotonin neurotoxin.It was withdrawnfrom human use after reports of heart valve damage and pulmonaryhypertension. From its structure, more apolar or hydrophobiccharacter than amphetamine, tropism for serotoninergicneurons would be expected. Likewise, thestructure suggests an indirect mechanism. If an indirectmechanism were operative, then all postsynaptic 5-HT receptors could be activated. Evidence from several studies indicatesthat the 5-HT<sub>1B</sub> and the 5-HT<sub>2C</sub> receptors are mostresponsible for the satiety effects of 5-HT. 5-HT may alsoinfluence the type of food selected (e.g., lower-fat food intake).The(+) isomer, dexfenfluramine (Redux), has agreater tropism for 5-HT systems than the racemic mixture.It, too, was withdrawn because of toxicity.
Lastest Price from Fenfluramine hydrochloride manufacturers
  • Fenfluramine hydrochloride
  • US $15.00-10.00/KG
  • CAS:404-82-0
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • 2021-08-12

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  • Company Name:Hangzhou Yuhao Chemical Technology Co., Ltd
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  • Products Intro:Product Name:fenfluraMine hydrochloride
    CAS:404-82-0
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  • Company Name:Shanghai Kewel Chemical Co., Ltd.
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    Purity:95+ HPLC; Package:10mg;25mg;50mg;100mg
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  • Company Name:Taizhou Ruixin Chemical Co., Ltd.
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    Purity:98% Package:1kg
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  • Company Name:Shenzhen Polymeri Biochemical Technology Co., Ltd.
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  • Products Intro:Product Name:Fenfluramine Hydrochloride
    CAS:404-82-0
    Package:Mg-g More...
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  • Company Name:Dideu Industries Group Limited
  • Tel:+86-29-89586680 +86-15129568250
  • Products Intro:Product Name:Fenfluramine hydrochloride
    CAS:404-82-0
    Purity:0.999 Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer
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  • Company Name:Career Henan Chemica Co
  • Tel:+86-0371-86658258 15093356674;
  • Products Intro:Product Name:fenfluramine hydrochloride
    CAS:404-82-0
    Purity:95%-99% crystal Liu Package:1KG;0.01USD
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