EPZ015666
1616391-65-1 Basic informationMore
- Product Name:EPZ015666
- Synonyms: EPZ015666 (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide GSK3235025 GSK-3235025 N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide EPZ-015666;EPZ 015666;GSK3235025 GSK3235025 (EPZ015666)
- CAS:1616391-65-1
- MF:C20H25N5O3
- MW:383.44
- EINECS:
- Mol File:1616391-65-1.mol
-
USE
EPZ015666 (GSK3235025) is an orally available inhibitor of protein arginine methyltransferase-5 (PRMT5), which is involved in diverse cellular processes, including tumorigenesis, and its overexpression is observed in cell lines and primary patient samples derived from lymphomas, particularly mantle cell lymphoma (MCL).EPZ015666 showed dose-dependent antitumor activity in multiplein vitroandin vivomantle cell lymphoma (MCL) models with treatment of MCL cell lines leading to inhibition of SmD3 methylation and cell death. Therefore, it is a potential drug candidate for future cancer therapy.
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- Company Name:Deyang Sino Biotech. Co., LTD
- Tel:+86-19182167371 +86-19182167371
- Products Intro:Product Name:EPZ-015666, GSK3235025
CAS:1616391-65-1
Purity:98% Package:100mg;1000mg;5000mg - CB Index:58
- Related Information:Catalog(99)
- Company Name:Sigma-Aldrich
- Tel:021-61415566 800-8193336
- Products Intro:Product Name:EPZ015666
CAS:1616391-65-1
Purity:>=98% (HPLC) Package:5mg, 25mg Remarks:SML1421 More... - CB Index:80
- Related Information:Catalog(51456)
- Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
- Tel:021-52996696，15000506266 15000506266
- Products Intro:Product Name:EPZ015666
CAS:1616391-65-1
Purity:98% HPLC Package:MG;G More... - CB Index:55
- Related Information:Catalog(4566)
- Company Name:Shanghaizehan biopharma technology co., Ltd.
- Tel:021-61350663 13052117465
- Products Intro:Product Name:EPZ015666
CAS:1616391-65-1
More... - CB Index:55
- Related Information:Catalog(1005)