Lorlatinib (PF-06463922)
1454846-35-5 Basic informationMore
- Product Name:Lorlatinib (PF-06463922)
- Synonyms: (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Lorlatinib,PF-06463922 PF-06463922, Lorlatinib (R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile Lorlatinib(PF0643922) High Purity API Lorlatinib Anaplastic lymphoma kinase (ALK) Lorlatinib Powder
- CAS:1454846-35-5
- MF:C21H19FN6O2
- MW:406.41
- EINECS:813-704-5
- Mol File:1454846-35-5.mol
-
USE
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and c-Ros oncogene 1 (ROS1, Ki = 0.7 nM). It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). PF-06463922 is orally available, displaying inhibition of ALK phosphorylation and antitumor efficacy in a xenograft model expressing EML4-L1196M ALK. It demonstrates efficient blood-brain barrier penetration, produces brain tumor regression in mice harboring EML4-ALK tumors, and increases overall survival.[Cayman Chemical]
Lastest Price from Lorlatinib (PF-06463922) manufacturers
- Lorlatinib
-
- US $0.00 /kg
- CAS:1454846-35-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10kg
- 2023-01-11
- lorlatinib
-
- US $200.00 /kg
- CAS:1454846-35-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000kg/Month
- 2022-11-29
Browse by Nationality 1454846-35-5 Suppliers >Global suppliers
Beijing (8) Shanghai (69) Chongqing (1) Sichuan (2) Guangdong (22) Zhejiang (15) Hunan (6) Hubei (45) Shandong (9) Henan (7) Hebei (17) Liaoning (1) Anhui (8) Jiangsu (38) Jiangxi (4) Hainan (2) Shaanxi (7) Hong Kong (5) Member (266) All (266)
Please select the suppliers
Recommend You Select Member Companies
Recommend You Select Member Companies
- Company Name:Changzhou jinhan pharmaceutical technology co., LTD
- Tel: 13917833665
- Products Intro:Product Name:Lorlatinib
CAS:1454846-35-5
Purity:98% Package:1kg， 1克 More... - CB Index:58
- Related Information:Catalog(130)
- Company Name:Suzhou Ryan Pharmaceutical Technology Co., Ltd.
- Tel:0512-68780025,68780026 18962125825
- Products Intro:Product Name:Lorlatinib (PF-06463922)
CAS:1454846-35-5
Purity:99%+ HPLC Package:1kg More... - CB Index:62
- Related Information:Catalog(142)
- Company Name:Shanghai Hope Chem Co., Ltd.，
- Tel: 18501659228
- Products Intro:Product Name:Lorlatinib
CAS:1454846-35-5
Purity:99.5%+ Remarks:1kg~10kg More... - CB Index:55
- Related Information:Catalog(323)
- Company Name:Nanjing Gold Pharmaceutical Technology Co. Ltd.
- Tel: 15905158493
- Products Intro:Product Name:PF-06463922
CAS:1454846-35-5
Purity:99% Package:1G 1KG 100KG More... - CB Index:55
- Related Information:Catalog(107)
- Company Name:Liuyang huarui material technology co., ltd.
- Tel: 13467605171
- Products Intro:Product Name:Lorlatinib
CAS:1454846-35-5
Purity:99% Package:1kg/Bag - CB Index:58
- Related Information:Catalog(182)
- Company Name:Hangzhou Chemtrue Bio-Tech Co.,Ltd.
- Tel:0571-83522824 19967494293
- Products Intro:Product Name:Lorlatinib
CAS:1454846-35-5
Purity:99% HPLC Package:100g,1KG,5KG,25KG - CB Index:58
- Related Information:Catalog(276)
- Company Name:Anqing Benro pharmachem Technology Co.,Ltd.
- Tel:05565209906 15391842992
- Products Intro:Product Name:Loratinib
CAS:1454846-35-5
Purity:99% Package:1g/RMB 100 - CB Index:58
- Related Information:Catalog(100)
- Company Name:Shanghai Zhen Li Biological Technology Co., Ltd
- Tel: 18516310516
- Products Intro:Product Name:PF-06463922
CAS:1454846-35-5
More... - CB Index:58
- Related Information:Catalog(2010)