ML216

• Product Name:ML216
• Synonyms: ML216 1-(4-Fluoro-3-(trifluoromethyl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea N-[4-Fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]urea CID 49852229 CID49852229 CID-49852229 ML 216; ML-216; CID-49852229; CID49852229; CID 49852229 CS-1561
• CAS:1430213-30-1
• MF:C15H9F4N5OS
• MW:383.32
• EINECS:
• Mol File:1430213-30-1.mol
• 

Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.[Cayman Chemical]

• Company Name:Sigma-Aldrich
• Tel:021-61415566 800-8193336
• Products Intro:Product Name:ML216
  CAS:1430213-30-1
  Purity:>=98% (HPLC) Package:5MG Remarks:SML0661-5MG More...
• CB Index:80
• Related Information:Catalog(51471)

• Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
• Tel:021-52996696，15000506266 15000506266
• Products Intro:Product Name:ML216
  CAS:1430213-30-1
  Purity:98% HPLC Package:MG;G More...
• CB Index:55
• Related Information:Catalog(4217)

• Company Name:Shanghai EFE Biological Technology Co., Ltd.
• Tel:021-65675885 18964387627
• Products Intro:Product Name:ML-216
  CAS:1430213-30-1
  Purity:98% Package:1mg;5mg;10mg
• CB Index:58
• Related Information:Catalog(9707)