AVL-292

• Product Name:AVL-292
• Synonyms: AVL-292 LMK-435 N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]- CC-292 (AVL-292) CC-292,LMK-435 N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide AVL292 CC-292
• CAS:1202757-89-8
• MF:C22H22FN5O3
• MW:423.44
• EINECS:
• Mol File:1202757-89-8.mol
• 

Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).[Cayman Chemical]

• AVL-292
• 
• US $0.00 /gram
• CAS:1202757-89-8
• Min. Order: 1gram
• Purity: 99%
• Supply Ability: 10kg
• 2022-02-18

• Company Name:Shanghai Beckham Medical Technology Co., Ltd
• Tel: 13816613772
• Products Intro:Product Name:AVL292
  CAS:1202757-89-8
  Purity:98% Package:10mg,50mg,100mg More...
• CB Index:55
• Related Information:Catalog(339)

• Company Name:Chembest Research Laboratories Limited
• Tel:021-20908456
• Products Intro:Product Name:AVL-292 (Spebrutinib)
  CAS:1202757-89-8
  Purity:98% More...
• CB Index:61
• Related Information:Catalog(6011)

• Company Name:Shanghai Hanhong Scientific Co.,Ltd.
• Tel:021-54306202 13764082696;
• Products Intro:Product Name:AVL-292
  CAS:1202757-89-8
  Purity:98% Remarks:GN020809 More...
• CB Index:64
• Related Information:Catalog(42982)

• Company Name:shanghai Rainbow MediTech.Co.Ltd.
• Tel:21-021-64968085,64968086-5815,5812 13918693646
• Products Intro:Product Name:N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide
  CAS:1202757-89-8
  Purity:99% HPLC Package:1g;10g;100g;1KG;5KG More...
• CB Index:65
• Related Information:Catalog(936)

• Company Name:Dalian Meilun Biotech Co., Ltd.
• Tel:0411-62910999 13889544652
• Products Intro:Product Name:AVL-292
  CAS:1202757-89-8
  Purity:>98%,BTK Package:20MG More...
• CB Index:58
• Related Information:Catalog(4647)

• Company Name:Shanghai Topbiochem Technology Co., Ltd
• Tel:021-58170097
• Products Intro:Product Name:AVL-292
  CAS:1202757-89-8
  Purity:98% Package:25g;100g;500g;1kg
• CB Index:58
• Related Information:Catalog(9442)