PF-03814735

• Product Name:PF-03814735
• Synonyms: PF-03814735 N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]acetamide Acetamide, N-[2-[(1S,4R)-6-[[4-(cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]- RYYNGWLOYLRZLK-RBUKOAKNSA-N CS-240 PF-03814735 USP/EP/BP Abecarnil Impurity 3 PF-03814735 PF03814735
• CAS:942487-16-3
• MF:C23H25F3N6O2
• MW:474.48
• EINECS:
• Mol File:942487-16-3.mol
• 

The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. PF-03814735 is a reversible inhibitor of both Aurora A and B kinases with IC50 values of 0.8 and 5 nM, respectively, in in vitro activity assays. PF-03814735 also inhibits the kinases FLT1, FAK, TrkA, Met, and FGFR1 with IC50 values of 10, 22, 30, 100, and 100 nM, respectively. PF-03814735 inhibits cell proliferation of HCT-116, HL-60, A549, and H125 tumor cell lines with IC50 values ranging from 42-150 nM and shows in vivo efficacy in an HCT-116 tumor xenograft mouse model. PF-03814735 has been shown to be particularly sensitive towards inhibiting the growth of small cell lung cancer cell lines and other tumors driven by the Myc family genes.[Cayman Chemical]

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:PF 03814735
  CAS:942487-16-3
  Package:10Mg,200Mg,50Mg,5Mg More...
• CB Index:76
• Related Information:Catalog(94657)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:PF 03814735
  CAS:942487-16-3
  Remarks:C14667 More...
• CB Index:61
• Related Information:Catalog(6005)

• Company Name:TargetMol Chemicals Inc.
• Tel:021-021-33632979 15002134094
• Products Intro:Product Name:PF-03814735
  CAS:942487-16-3
  Package:2mg/RMB 678 More...
• CB Index:58
• Related Information:Catalog(7783)