CCG-100602
1207113-88-9 Basic informationMore
- Product Name:CCG-100602
- Synonyms: CCG-100602 1-[3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)piperidine-3-carboxamide 3-Piperidinecarboxamide, 1-[3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)- CCG-100602 >=98% (HPLC) CCG 100602,Inhibitor,transcription,inhibit,serum,myocardin,nuclear,SRF,CCG100602,MRTF-A,CCG-100602,Ras,localization
- CAS:1207113-88-9
- MF:C21H17ClF6N2O2
- MW:478.82
- EINECS:
- Mol File:1207113-88-9.mol
-
USE
The Rho family of small GTPases play an important role in transduction of cell signaling events associated with several human cancers. CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. The site of inhibition in the pathway is not precisely defined but CCG-1423 appears to act on some aspect of the interaction of SRF with its transcriptional cofactor megakaryoblastic leukemia 1 (MKL1) at a point upstream of DNA binding. CCG-100602 is a CCG-1423 analog developed for improved selectivity, potency, and attenuated cytotoxicity relative to its parent compound. CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells with an IC50 value of 9.8 μM. At 100 μM, CCG-100602 demonstrates 72% inhibition of PC-3 cell invasion into a Matrigel model of metastasis, exhibiting an efficacy:toxicity profile superior to that of CCG-1423 at 10 μM.[Cayman Chemical]
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- Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
- Tel:021-52996696，15000506266 15000506266
- Products Intro:Product Name:CCG-100602
CAS:1207113-88-9
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g - CB Index:55
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- Company Name:ShangHai Biochempartner Co.,Ltd
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CAS:1207113-88-9
Purity:98% HPLC LCMS Package:100MG;1G - CB Index:62
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- Company Name:Shanghai Chaolan Chemical Technology Center
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CAS:1207113-88-9
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G - CB Index:58
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- Company Name:DC Chemicals
- Tel:021-58447131 13564518121
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CAS:1207113-88-9
Purity:98% HPLC Package:100mg，250mg，1g - CB Index:58
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- Company Name:Energy Chemical
- Tel:021-58432009 400-005-6266
- Products Intro:Product Name:CCG-100602 >=98% (HPLC)
CAS:1207113-88-9
Purity:NULL Package:1ea;25mg;5mg Remarks:NULL - CB Index:58
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- Company Name:MedBioPharmaceutical Technology Inc
- Tel:021-69568360 18916172912
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CAS:1207113-88-9
Purity:98% Package:50mg; 25mg; 10mg Remarks:Medbio - CB Index:58
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- Company Name:Jinan Jiuli Biotechnology Co. , Ltd.
- Tel:2717893647 14768611851
- Products Intro:Product Name:CCG-100602
CAS:1207113-88-9
Purity:98% Package:500mg；1g；5g - CB Index:58
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