4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
188591-46-0 Basic informationMore
- Product Name:4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
- Synonyms: 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide GSK 3787 GSK3787/GSK-3787 Benzamide, 4-chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]- 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-benzamide GSK 3787 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide 4-chloro-N-(2-(5-(trifluoromethyl)pyridin-2-ylsulfonyl)ethyl)benzamide GSK3787;GSK 3787;GSK-3787
- CAS:188591-46-0
- MF:C15H12ClF3N2O3S
- MW:392.78
- EINECS:
- Mol File:188591-46-0.mol
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USE
<p>PPARβ/δ is thought to play a role in lipid homeostasis and glucose disposal by regulating genes involved in fatty acid oxidation, reverse cholesterol transport, and carbon substrate utilization in skeletal muscle. It has also been implicated in the progression of certain cancers. GSK3787 is an irreversible antagonist of PPARβ/δ (pIC50 = 6.6) with no measurable affinity for PPARα or PPARγ (pIC50 >5). At 1μM, it inhibits the expression of PPARβ/δ-regulated target genes, pyruvate dehydrogenase kinase 4 and carnitine palmitoyl transferase 1a, which are important for energy homeostasis in human skeletal muscle cells. GSK3787 (at 1 μM) also antagonizes agonist-induced expression of angiopoietin-like protein 4 in mouse fibroblasts, mouse keratinocytes, and human MCF-7, Huh7, and HepG2 cancer cell lines.[Cayman Chemical]</p>
Lastest Price from 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide manufacturers
- 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
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- US $0.00-0.00/KG
- CAS:188591-46-0
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1Ton
- 2022-10-14
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- Company Name:WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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- Products Intro:Product Name:GSK-3787
CAS:188591-46-0
Purity:98% HPLC Package:50.0mg;100.0mg; 200.0mg;500mg;1g;5g; 10g More... - CB Index:64
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- Company Name:J & K SCIENTIFIC LTD.
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- Products Intro:Product Name:4-Chloro-N-[2-[[5-(trifluoroMethyl)-2-pyridinyl]sulfonyl]ethyl]benzaMide
CAS:188591-46-0
Package:10Mg,50Mg More... - CB Index:76
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:GSK 3787;4-Chloro-N-[2-[[5-(trifluoroMethyl)-2-pyridinyl]sulfonyl]ethyl]benzaMide
CAS:188591-46-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:Shanghai Hanhong Scientific Co.,Ltd.
- Tel:021-54306202 13764082696
- Products Intro:Product Name:GSK3787
CAS:188591-46-0
Purity:98% Remarks:GN021179 More... - CB Index:64
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- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel:400-400-6206333 18521732826
- Products Intro:Product Name:GSK3787
CAS:188591-46-0
Purity:>=98% Package:10mg/RMB 146.90;250mg/RMB 1799.90;50mg/RMB 514.90 More... - CB Index:65
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