Mirin
299953-00-7 Basic informationMore
- Product Name:Mirin
- Synonyms: 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one MRN-ATM Pathway Inhibitor, Mirin (5E)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one (E)-5-(4-hydroxybenzylidene)-2-iminothiazolidin-4-one 4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]- Mirin >=98% (HPLC), powder
- CAS:299953-00-7
- MF:C10H8N2O2S
- MW:220.25
- EINECS:683-709-3
- Mol File:299953-00-7.mol
-
USE
The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during DNA replication, and activates and recruits ataxia-telangiectasia mutated (ATM) to damaged DNA. The genes that encode the MRN proteins are all essential for cell viability, so functional studies of MRN cannot involve deletion of these genes. Mirin is an inhibitor of MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Through its effects on MRN, mirin prevents activation of ATM. Inhibition of MRN centers on the ability of mirin to block the nuclease activity of Mre11, rather than altering DNA-binding or MRN complex formation. In cells, mirin induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed repair of DNA damage.[Cayman Chemical]
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- Company Name:Sigma-Aldrich
- Tel:021-61415566 800-8193336
- Products Intro:Product Name:Mirin
CAS:299953-00-7
Purity:>=98% (HPLC) Package:5mg, 25mg Remarks:M9948 More... - CB Index:80
- Related Information:Catalog(51471)
- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:Mirin
CAS:299953-00-7
Purity:95% Package:2mg;5mg;10mg More... - CB Index:58
- Related Information:Catalog(9806)
- Company Name:Angel Pharmatech, Ltd.
- Tel: 17317130613
- Products Intro:Product Name:Mirin
CAS:299953-00-7
Purity:98% HPLC Package:1G;5G More... - CB Index:58
- Related Information:Catalog(3250)
- Company Name:Block Chemical Technology (Shanghai) Co., LTD
- Tel:021-20432219 13918097649
- Products Intro:Product Name:(5E)-5-(4-hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
CAS:299953-00-7
Purity:0.95 Package:5g,250g,1kg Remarks:3.4855 - CB Index:58
- Related Information:Catalog(9562)
- Company Name:TargetMol Chemicals Inc.
- Tel: 4008200310
- Products Intro:Product Name:Mirin
CAS:299953-00-7
Purity:0 Package:2mg/RMB 333 - CB Index:58
- Related Information:Catalog(24647)
- Company Name:Nantong QuanYi Biotechnology Co., Ltd
- Tel:0513-66337626 18051384581
- Products Intro:Product Name:Mirin
CAS:299953-00-7
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，more - CB Index:58
- Related Information:Catalog(4679)