R-406

• Product Name:R-406
• Synonyms: R-406 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one R406(free base) R-406 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one R406 (free base), >=98% R406 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
• CAS:841290-80-0
• MF:C22H23FN6O5
• MW:470.45
• EINECS:617-533-5
• Mol File:841290-80-0.mol
• 

R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.[Cayman Chemical]

• R-406
• 
• US $0.00 /kg
• CAS:841290-80-0
• Min. Order: 1kg
• Purity: 0.99
• Supply Ability: 20tons
• 2024-10-25

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:6-[[5-Fluoro-2-[(3,4,5-triMethoxyphenyl)aMino]-4-pyriMidinyl]aMino]-2,2-diMethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one
  CAS:841290-80-0
  Package:500Mg,50Mg More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:R406 free base
  CAS:841290-80-0
  Remarks:C14075 More...
• CB Index:61
• Related Information:Catalog(6005)

• Company Name:Shanghai Kuanghao Chemistry Technology Co., Ltd.
• Tel:13130049594 13130049594
• Products Intro:Product Name:R-406
  CAS:841290-80-0
  Purity:>99% Package:50Mg 100Mg 1g More...
• CB Index:57
• Related Information:Catalog(95)

• Company Name:QINGDAO CARELONGPHARMATECH CO.,LTD
• Tel:0532-0532-88191853 13061484198
• Products Intro:Product Name:6-[5-Fluoro-2-(3,4,5-triMethoxy-phenylaMino)-pyriMidin-4-ylaMino]-2,2-diMethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
  CAS:841290-80-0
  Purity:>97% Package:100Mg;1g;5g;More More...
• CB Index:57
• Related Information:Catalog(413)

• Company Name:Dalian Meilun Biotech Co., Ltd.
• Tel:0411-62910999 13889544652
• Products Intro:Product Name:R-406
  CAS:841290-80-0
  Purity:>98% Package:50MG Remarks:4390 More...
• CB Index:58
• Related Information:Catalog(4727)