PHA 767491 HYDROCHLORIDE

• Product Name:PHA 767491 HYDROCHLORIDE
• Synonyms: PHA-767491 CAY10572 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one PHA 767491 HYDROCHLORIDE 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-onehydrochloride 2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one 2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one PHA-767491HCL
• CAS:845714-00-3
• MF:C12H11N3O
• MW:213.24
• EINECS:
• Mol File:845714-00-3.mol
• 

<p>Cdc7 kinase is a key regulator of the S-phase of the cell cycle. It is known to promote the activity of DNA replication origins in eukaryotic organisms. Inhibition of Cdc7 kinase causes blockade of DNA synthesis in human cell lines. Tumor cells are then funneled into the apoptotic pathway in a p53-independent manner. Pharmacological inhibition of Cdc7 kinase can be an effective strategy for the development of oncologic therapeutics useful for treatment of cancers. PHA 767491 HYDROCHLORIDE is a potent inhibitor of Cdc7 kinase with an IC50 value of 10 nM in the presence of 1.5 μM ATP. At 10 μM, PHA 767491 HYDROCHLORIDE induces apoptotic cell death in multiple cancer cell types. PHA 767491 HYDROCHLORIDE also inhibits Cdk9, a kinase involved in the phosphorylation of RNA polymerase II and in transcriptional regulation of gene expression, with an IC50 value of 34 nM.[Cayman Chemical]</p>

• Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
• Tel:821-50328103-801 18930552037
• Products Intro:Product Name:PHA 767491 hydrochloride;1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-onehydrochloride
  CAS:845714-00-3
  Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
• CB Index:69
• Related Information:Catalog(15839)

• Company Name:Dalian Meilun Biotech Co., Ltd.
• Tel:0411-62910999 13889544652
• Products Intro:Product Name:PHA 767491 HYDROCHLORIDE
  CAS:845714-00-3
  Purity:>98% Package:50MG Remarks:2670 More...
• CB Index:58
• Related Information:Catalog(4727)

• Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
• Tel:400-400-6206333 18521732826
• Products Intro:Product Name:PHA-767491
  CAS:845714-00-3
  Purity:>=98% Package:100mg/RMB 3398.90;25mg/RMB 1029.90;5mg/RMB 308.90 More...
• CB Index:65
• Related Information:Catalog(25003)

• Company Name:Shanghai Run-Biotech Co., Ltd.
• Tel:021-57171705 13817537615
• Products Intro:Product Name:PHA-767491(HCl)
  CAS:845714-00-3
  Purity:98% Package:10g/
• CB Index:58
• Related Information:Catalog(2395)

• Company Name:DKMbiochem.Co. Ltd
• Tel: 15901859516
• Products Intro:Product Name:PHA 767491
  CAS:845714-00-3
  Purity:0.98 Package:100mg,250mg,500mg,1g,5g,10g,25.g,100g
• CB Index:58
• Related Information:Catalog(344)

• Company Name:Shanghai YuLue Chemical Co., Ltd.
• Tel:021-60345187 13671753212
• Products Intro:Product Name:PHA767491
  CAS:845714-00-3
  Purity:98% Package:1g，5g，10g，500g，1kg
• CB Index:55
• Related Information:Catalog(10274)