LUFFARIELLOLIDE
111149-87-2 Basic informationMore
- Product Name:LUFFARIELLOLIDE
- Synonyms: LUFFARIELLOLIDE 4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone 4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one 3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one 2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-
- CAS:111149-87-2
- MF:C25H38O3
- MW:386.57
- EINECS:
- Mol File:111149-87-2.mol
-
USE
Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation. It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM). Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors. In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth. It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).[Cayman Chemical]
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- Company Name:Shanghai EFE Biological Technology Co., Ltd.
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- Products Intro:Product Name:Luffariellolide
CAS:111149-87-2
Purity:98% Package:1mg More... - CB Index:58
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CAS:111149-87-2
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- Company Name:MedBioPharmaceutical Technology Inc
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- Products Intro:Product Name:LUFFARIELLOLIDE
CAS:111149-87-2
Purity:98% Package:1mg Remarks:Medbio - CB Index:58
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- Company Name:Wuhan Topule
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Purity:98% Remarks:100mg - CB Index:58
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- Company Name:QUALITY CONTROL SOLUTIONS LTD.
- Tel:0755-66853366; 13670046396
- Products Intro:Product Name:Luffariellolide
CAS:111149-87-2
Purity:95% HPLC Package:10MG;25MG;50MG;100MG - CB Index:58
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- Company Name:Wuhan Augda Biotechnology Co., Ltd
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- Products Intro:Product Name:Luffariellolide
CAS:111149-87-2
Purity:98% Package:mg；g；kg - CB Index:58
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