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Indole-3-carboxaldehyde

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Indole-3-carboxaldehyde (I3A), also known as indole-3-aldehyde and 3-formylindole, is a metabolite of dietary l-tryptophan which is synthesized by human gastrointestinal bacteria, particularly species of the Lactobacillus genus.I3A is a biologically active metabolite which acts as a receptor agonist at the aryl hydrocarbon receptor in intestinal immune cells, in turn stimulating the production of interleukin-22 which facilitates mucosal reactivity.
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