3-Chloro-5-hydroxy-benzoic acid
53984-36-4 Basic informationMore
- Product Name:3-Chloro-5-hydroxy-benzoic acid
- Synonyms: 5-(hydroxy)-3-chlorobenzoic acid 5-Chloro-m-salicylic Acid 3-chloro-5-hydroxy BA Benzoic acid, 3-chloro-5-hydroxy- GPR81 Agonist, 3Cl-5OH-BA GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem 3-chloro-5-hydroxybenzoic Acid, 10 mM in DMSO 3-Chloro-5-hydroxy-benzoic acid
- CAS:53984-36-4
- MF:C7H5ClO3
- MW:172.57
- EINECS:
- Mol File:53984-36-4.mol
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USE
GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 μM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.[Cayman Chemical]
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- 3-CHLORO-5-HYDROXY-BENZOIC ACID
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- CAS:53984-36-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
- 2025-04-04
- 3-CHLORO-5-HYDROXY-BENZOIC ACID
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- $3.00
- CAS:53984-36-4
- Min. Order: 1KG
- Purity: 98%
- 2024-03-26
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