IL-1R Antagonist is a cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR domain BB-loop of IL-1RI. It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. Has shown to activate the MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
