ジメチルエイコサジエン酸

7,7-Dimethyleicosadienoic Acid (DEDA) is an arachidonic acid analog that inhibits PLA2 (phospholipase A2). 7,7-Dimethyleicosadienoic Acid (DEDA) is reported to inhibit SRS-A biosynthesis occurring in peritoneal cells. This compound has been found to also inhibit P388D1 cell PLA2 and snake venom PLA2. DEDA has been shown to selectively inhibit human recombinant sPLA2 over cPLA2. This compound also weakly inhibits 5-LO (5-lipoxygenase).