3,5-Dimethyl-4-nitroisoxazole was used in the synthesis of:series of methylene bis-isoxazolo[4,5-b]azepines, via reaction with methylenebis-chalconesphenylmethylene bis-isoxazolo[4,5-b]azepine derivatives3-arylglutaric acids, bis-isoxazoles and bis-pyrazoles