U-83836E prevents hydrogen peroxide-induced F2 isoprostane production in renal proximal tubular cells, prevents free radical mediated effects of oxyhemoglobin in vascular smooth muscle, and reduces secondary brain injury in a rabbit model of cryogenic trauma. Research shows that U-83836E improves survival of rat embryonic mesencephalic tissue stored at 4C, and mitigates the toxicity of methanol on the antioxidant system of the rat brain. Western blot of cardiac tissue pretreated with U-83836E shows increase expression of HSP 70 (HSP72).
