Tipiracil hydrochloride

$5 - $2060

Product nameTipiracil hydrochloride
Cas No183204-72-0
MFC9H12Cl2N4O2
MW279.12318
MDL NumberMFCD01571384

Synonyms

Tipiracil (hydrochloride);2,4(1H,3H)-PyriMidinedione,5-chloro-6-[(2-iMino-1-pyrrolidinyl)Methyl] hydrochloride;5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione monohydrochloride;Tipiracil HCl;5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione,hydrochloride;5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione hydrochloride;5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)uracil hydrochloride;Tipiracil hydrochloride(TPI)

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Price

88 prices

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Arctom aablocks Cayman Chemical ApexBio Technology ChemScene Biosynth AK Scientific Matrix Scientific TRC Sigma-Aldrich CSNpharm Crysdot AccelPharmtech DC Chemicals American Custom Chemicals Corporation
Package less more

1mg 5mg 10mg 25mg 50mg 100mg 200mg 250mg 500mg 1000mg 1.00g 10mm(in1mlh2o) 10mm*1mlinwater(solid+solvent) 1g 2000mg 2g 5000mg 5g 5.00g 10000mg 10mm*1mlinwater(solution) 10g 25.00g 25g 100g

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Brand	Packaging	Price	Product name
aablocks AA00AOI5	5mg	$8	Tipiracil HCl
aablocks AA00AOI5	10mg	$10	Tipiracil HCl
aablocks AA00AOI5	25mg	$12	Tipiracil HCl
aablocks AA00AOI5	50mg	$15	Tipiracil HCl
aablocks AA00AOI5	100mg	$20	Tipiracil HCl
aablocks AA00AOI5	250mg	$28	Tipiracil HCl
aablocks AA00AOI5	1g	$52	Tipiracil HCl
aablocks AA00AOI5	5g	$178	Tipiracil HCl
aablocks AA00AOI5	25g	$757	Tipiracil HCl
AccelPharmtech WW1462	100G	$2060	Tipiracilhydrochloride

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Properties

Melting point	245℃ (decomposition)
storage temp.	2-8°C
solubility	DMSO (Slightly, Heated), Water (Slightly)
form	powder
color	white to beige
Water Solubility	H2O: 5mg/mL, clear (warmed)
Stability	Hygroscopic
InChI	InChI=1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H
InChIKey	KGHYQYACJRXCAT-UHFFFAOYSA-N
SMILES	C1(=O)NC(CN2CCCC2=N)=C(Cl)C(=O)N1.[H]Cl

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

Tipiracil (TPI) is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC₅₀ value of 35 nM for human placental TPase. It is selective for TPase over other pyrimidine-metabolizing enzymes (IC₅₀s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine , a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.

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Suppliers and manufacturers

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Tipiracil hydrochloride

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Beijing Cooperate Pharmaceutical Co.,Ltd
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Antai Fine Chemical Technology Co.,Limited
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