Terutroban

$29 - $2541.5

Product nameTerutroban
Cas No165538-40-9
MFC20H22ClNO4S
MW407.91
MDL NumberMFCD28411833

Synonyms

Terutroban;S 18886;S18886;3-[(6R)-6-[(4-CHLOROPHENYL)SULFONYLAMINO]-2-METHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL]PROPANOIC ACID;(R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid;Triplion;(6R)-6-[[(4-chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid;3-[(6R)-6-[(4-CHLOROPHENYL)SULFONYLAMINO]-2-METHYL-5,6,7,8-TETRAHYDROPHTHALEN-1-YL]PROPANOIC ACID

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Price

38 prices

Brand less more

aablocks Crysdot ApexBio Technology Arctom ChemScene Cayman Chemical Sigma-Aldrich Tocris ACHEMBLOCK Ambeed AK Scientific TRC Biosynth DC Chemicals Biorbyt Ltd
Package less more

10 1mg 5mg 10mg 25mg 50mg 10mm*1mlindmso(solid+solvent) 100mg 250mg 1g 10mm*1mlindmso(solution)

Clear All Done

Brand	Packaging	Price	Product name
aablocks AA001W51	10mg	$46	Terutroban
aablocks AA001W51	1mg	$29	Terutroban
aablocks AA001W51	25mg	$109	Terutroban
aablocks AA001W51	50mg	$196	Terutroban
ACHEMBLOCK Y228502	100MG	$470	Terutroban
ACHEMBLOCK Y228502	25MG	$165	Terutroban
AK Scientific 4354CR	10mg	$220	Terutroban
Ambeed A287410	25mg	$208	Terutroban
Ambeed A287410	50mg	$312	Terutroban
Ambeed A287410	100mg	$470	Terutroban

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Properties

Melting point	189 - 192°C
Boiling point	591.8±60.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	4.60±0.10(Predicted)
form	Solid
color	White to Off-White
optical activity	[α]/D 25 to 31°, c =1 in DMSO
InChI	1S/C20H22ClNO4S/c1-13-2-3-14-12-16(6-9-19(14)18(13)10-11-20(23)24)22-27(25,26)17-7-4-15(21)5-8-17/h2-5,7-8,16,22H,6,9-12H2,1H3,(H,23,24)/t16-/m0/s1
InChIKey	HWEOXFSBSQIWSY-INIZCTEOSA-N
SMILES	O=S(N[C@@H]1CC2=CC=C(C)C(CCC(O)=O)=C2CC1)(C3=CC=C(Cl)C=C3)=O

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321：Specific treatment (see … on this label).

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P362：Take off contaminated clothing and wash before reuse.

Description

The lipid mediator thromboxane A₂ (TXA₂) plays a key role in platelet aggregation and vascular and bronchial smooth muscle constriction. The actions of TXA₂ are mediated by its specific G protein coupled-receptor, referred to as the TXA₂ receptor or TP. S18886 is an orally active, long-acting antagonist of the TP receptor with an IC₅₀ value of 16.4 nM. It inhibits TP receptor-mediated vascular contractions, platelet aggregation, and adhesion and infiltration of monocytes/macrophages in various pre-clinical and clinical models of thrombosis or atherosclerosis. S18886 is the active isomer of the potent TP receptor antagonist, S18204. Antagonists of TP receptors have advantages over aspirin as they not only block the effect of TXA₂ on platelets, but also inhibit other ligands such as prostaglandin endoperoxides and isoprostanes.

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3-(4-CYCLOPROPYLSULFAMOYL-PHENYL)-PROPIONIC ACID $110-1506.05

Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd.
LGM Pharma
Nanjing Norris-Pharm Technology Co., Ltd
Haoyuan Chemexpress Co., Ltd.
MedChemexpress LLC
Guangzhou Isun Pharmaceutical Co., Ltd
Shanghai Synchem Pharma Co., ltd
Guangzhou QiYun Biotechnology Co., Ltd.
ShangHai Biochempartner Co.,Ltd
Amadis Chemical Company Limited

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