Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels in the central and peripheral nervous system. SR 16584 is an antagonist of the α3β4 nAChR subtype (IC50 = 10.2 μM). It shows selective binding of the α3β4 subtype compared to the α4β2 and α7 subtypes (Ki values of 0.508, >100, and >100 μM, respectively), indicating that it should be a useful tool for receptor subtype studies.
