When used with aliphatic or aromatic aldehydes, this silicon amine protocol
SLAP reagent enables the photomediated synthesis of thiomorpholines and thiazepanes. For photocatalytic cross-coupling with this SLAP Reagent, Ir[(ppy)
2dtbbpy]PF
6 (
747769) is used with a recommended starting combination of Lewis acids Bi(OTf)
3 (
633305) and Cu(OTf)
2 (
283673) prior to subsequent substrate-specific optimization. This product was introduced in collaboration with the
Bode Research Group and provides a tin-free alternative to
SnAP (tin amine protocol) reagents and is well-suited for scale-up reactions.
