Olodaterol

$56 - $1888

Product nameOlodaterol
Cas No868049-49-4
MFC21H26N2O5
MW386.44
EINECS813-858-3
MDL NumberMFCD16619349

Synonyms

6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one;2H-1,4-Benzoxazin-3(4H)-one, 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-;BI 1744(Olodaterol;Striverdi Respimat);Olodaterol;Olodaterol ImpurityＡ　;BI-1744;Striverdi

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Price

43 prices

Brand less more

Biosynth ChemScene Cayman Chemical Biorbyt Ltd Crysdot AK Scientific DC Chemicals American Custom Chemicals Corporation Chemenu
Package less more

1mg 2mg 5mg 10mg 25mg 50mg 100mg 250mg 1g

Clear All Done

Brand	Packaging	Price	Product name
AK Scientific 4736BB	2mg	$171	Olodaterol
American Custom Chemicals Corporation API0014046	5MG	$501.28	OLODATEROL
Biorbyt Ltd orb1223805	10mg	$510	Olodaterol
Biorbyt Ltd orb1223805	5mg	$350	Olodaterol
Biorbyt Ltd orb1223805	2mg	$210	Olodaterol
Biorbyt Ltd orb2276859	5mg	$240	Olodaterol
Biorbyt Ltd orb2276859	1mg	$90	Olodaterol
Biorbyt Ltd orb1223805	25mg	$980	Olodaterol
Biosynth FH152793	25mg	$325	Olodaterol
Biosynth FH152793	50mg	$1180	Olodaterol

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Properties

Boiling point	649.0±55.0 °C(Predicted)
Density	1.250
solubility	DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 15 mg/ml; Ethanol: 1 mg/ml
form	A crystalline solid
pka	9.42±0.20(Predicted)
color	Light yellow to khaki
Stability	Hygroscopic

Safety Information

Symbol(GHS)

Signal word

Danger

Hazard statements

H302：Harmful if swallowed

H319：Causes serious eye irritation

H372：Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260：Do not breathe dust/fume/gas/mist/vapours/spray.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314：Get medical advice/attention if you feel unwell.

P330：Rinse mouth.

P501：Dispose of contents/container to..…

Description

In 2013, olodaterol (also known BI-1744 CL) was approved for the treatment of chronic obstructive pulmonary disease (COPD) in Russia (March), Canada (June), and the EuropeanUnion (October). Olodaterol is delivered via the Respimat Soft Mist inhaler. Olodaterol was discovered from an effort to identify a β2-adrenergic receptor agonist that could be given once daily and with a superior safety profile over known β2- adrenergic receptor agonists. Olodaterol is a potent β2 agonist (EC₅₀=0.1 nM, intrinsic activity=88%) and is highly selective for the β2 receptor over β1 and β3 receptors. In preclinical models in guinea pigs and dogs, olodaterol had a rapid onset of action and provided bronchoprotection over 24 h. Mechanistic studies indicated that olodaterol forms a highly stable complex with the β2-adrenergic receptor, with a dissociation half-life of 17.8 h. The synthesis of olodaterol proceeds through an (R)-styrene epoxide that is prepared via enantioselective reduction of an α-chloroketone intermediate. Ring opening of the epoxide with 1-(4- methoxyphenyl)-2-methylpropan-2-amine provides olodaterol.

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