Nafarelin acetate is a synthetic decapeptide agonist analog of the natural
gonadotropin-releasing hormone, differing in the amino acid at position 6 where
D-naphthylalanine has been substituted for glycine. This substitution gives nafarelin
greater potency and a substantially longer half-life than the endogenous hormone.
Nafarelin acetate administered as a nasal spray, suppresses estrogen levels on repeated
dosing and is indicated for the management of endometriosis. It also has orphan drug
status for use in precocious puberty.
