ML 10302 hydrochloride is a potent SR-4 partial agonist (EC50 = 4 nM) that displays > 680-fold selectivity over SR-3 (Ki values are 1.07 and 730 nM, respectively). ML 10302 hydrochloride increases sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibits progastrokinetic effects in vivo.
