LY411575

$34 - $4023.9

Product nameLY411575
Cas No209984-57-6
MFC26H23F2N3O4
MW479.48
MDL NumberMFCD09832551

Synonyms

LY411575;(aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide;(S)-2-(2-(3,5-difluorophenyl)acetaMido)-N-((S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanaMide;Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-;(aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide LY 411575;LY 411575 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide;LSN-411575;N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide

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Price

66 prices

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aablocks Cayman Chemical Arctom Ambeed ApexBio Technology ChemScene TCI Chemical AK Scientific Sigma-Aldrich Ark Pharm DC Chemicals Biosynth Crysdot American Custom Chemicals Corporation Usbiological CSNpharm Biorbyt Ltd Matrix Scientific
Package less more

0.5mg 50.00mg 100mg 10mm(1mlindmso) 100.00mg 250mg 1000mg 1g 1mg 2mg 5mg 10mg 10mm*1mlindmso 25mg 10mm(in1mldmso) 50mg

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Brand	Packaging	Price	Product name
aablocks AA002KFF	1mg	$34	LY411575
aablocks AA002KFF	2mg	$51	LY411575
aablocks AA002KFF	5mg	$69	LY411575
aablocks AA002KFF	10mg	$70	LY411575
aablocks AA002KFF	25mg	$92	LY411575
aablocks AA002KFF	50mg	$155	LY411575
aablocks AA002KFF	100mg	$261	LY411575
AK Scientific 2530AH	5mg	$132	(2S)-2-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][3]benzazepin-7-yl]propanamide
AK Scientific 2530AH	10mg	$170	(2S)-2-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][3]benzazepin-7-yl]propanamide
Ambeed A140795	50mg	$178	LY411575

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Properties

Boiling point	836.0±65.0 °C(Predicted)
Density	1.40
storage temp.	-20°C
solubility	DMSO: soluble5mg/mL, clear
form	powder
pka	11.79±0.20(Predicted)
color	white to beige
InChIKey	ULSSJYNJIZWPSB-CVRXJBIPSA-N
SMILES	C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]2C(=O)N(C)c3ccccc3-c4ccccc24

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that has been shown to block Notch activation in vitro at 500 μM. LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis. It has also been observed to promote neural differentiation of mouse embryonic stem cells.

Related product price

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Suppliers and manufacturers

career henan chemical co

LY411575

CAS:209984-57-6
TargetMol Chemicals Inc.

$38.00

LY-411575

CAS:209984-57-6
ATK CHEMICAL COMPANY LIMITED
Biochempartner
CONIER CHEM AND PHARMA LIMITED
ANHUI WITOP BIOTECH CO., LTD
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
HANGZHOU LEAP CHEM CO., LTD.

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